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Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.
Nakano H, Nakajima A, Sakon-Komazawa S, Piao JH, Xue X, Okumura K. Nakano H, et al. Cell Death Differ. 2006 May;13(5):730-7. doi: 10.1038/sj.cdd.4401830. Cell Death Differ. 2006. PMID: 16341124 Review.
Recent studies have indicated that one of the antiapoptotic functions of NF-kappaB is to downregulate JNK activation. Further studies have also revealed that NF-kappaB inhibits JNK activation by suppressing accumulation of reactive …
Recent studies have indicated that one of the antiapoptotic functions of NF-kappaB is to downregulate JNK activation. F …
Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.
Wullaert A, Heyninck K, Beyaert R. Wullaert A, et al. Biochem Pharmacol. 2006 Oct 30;72(9):1090-101. doi: 10.1016/j.bcp.2006.07.003. Epub 2006 Aug 24. Biochem Pharmacol. 2006. PMID: 16934229 Review.
However, during the past few years it has become clear that NF-kappaB-mediated inhibition of cell death also involves attenuating TNF-induced activation of c-Jun activating kinase (JNK). ...In this review, we will discuss the various mechanisms by whic …
However, during the past few years it has become clear that NF-kappaB-mediated inhibition of cell death also involves a …
Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance.
Bubici C, Papa S, Dean K, Franzoso G. Bubici C, et al. Oncogene. 2006 Oct 30;25(51):6731-48. doi: 10.1038/sj.onc.1209936. Oncogene. 2006. PMID: 17072325 Review.
Reactive oxygen species (ROS) are emerging as key effectors in signal transduction. ...Effectors of this antagonistic cross-talk between NF-kappaB and ROS/JNK pathways have recently been identified. ...
Reactive oxygen species (ROS) are emerging as key effectors in signal transduction. ...Effectors of this antagonistic …
TNF receptor superfamily-induced cell death: redox-dependent execution.
Shen HM, Pervaiz S. Shen HM, et al. FASEB J. 2006 Aug;20(10):1589-98. doi: 10.1096/fj.05-5603rev. FASEB J. 2006. PMID: 16873882 Review.
Of particular interest is the intermediary role of intracellular reactive oxygen species (ROS) in signal transduction after ligation of the TNFR1. ...Recently, some important discoveries have underscored the critical role of ROS in TNFalpha signaling, notably …
Of particular interest is the intermediary role of intracellular reactive oxygen species (ROS) in signal transduction a …
Lobaplatin induces pyroptosis through regulating cIAP1/2, Ripoptosome and ROS in nasopharyngeal carcinoma.
Chen Z, Xu G, Wu D, Wu S, Gong L, Li Z, Luo G, Hu J, Chen J, Huang X, Chen C, Jiang Z, Li X. Chen Z, et al. Biochem Pharmacol. 2020 Jul;177:114023. doi: 10.1016/j.bcp.2020.114023. Epub 2020 May 13. Biochem Pharmacol. 2020. PMID: 32413426
Lobaplatin, as an effective third-generation platinum with fewer adverse reactions and less platinum cross-resistance, has been considered as a good alternative to cisplatin after cisplatin's failure (relapse or metastasis) in the treatment of NPC. ...Importa …
Lobaplatin, as an effective third-generation platinum with fewer adverse reactions and less platinum cross-resistance, has bee …
Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways.
Mi Y, Xiao C, Du Q, Wu W, Qi G, Liu X. Mi Y, et al. Free Radic Biol Med. 2016 Jan;90:230-42. doi: 10.1016/j.freeradbiomed.2015.11.022. Epub 2015 Nov 22. Free Radic Biol Med. 2016. PMID: 26593748
Momordin Ic simultaneously induces autophagy and apoptosis by suppressing the ROS-mediated PI3K/Akt and activating the ROS-related JNK and P38 pathways. Additionally, momordin Ic induces apoptosis by suppressing PI3K/Akt-dependent NF-kappaB pathways an …
Momordin Ic simultaneously induces autophagy and apoptosis by suppressing the ROS-mediated PI3K/Akt and activating the ROS-related …
Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis.
Panzhinskiy E, Ren J, Nair S. Panzhinskiy E, et al. PLoS One. 2013 Oct 18;8(10):e77228. doi: 10.1371/journal.pone.0077228. eCollection 2013. PLoS One. 2013. PMID: 24204775 Free PMC article. Retracted.
Treatment of C2C12 myotubes with the ER-stressor tunicamycin resulted in the accumulation of reactive oxygen species (ROS), leading to the activation of protein expression of PTP1B. Furthermore, tunicamycin-induced ROS production activated nuclear translocati …
Treatment of C2C12 myotubes with the ER-stressor tunicamycin resulted in the accumulation of reactive oxygen species (R …
Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways.
El Jamal SM, Taylor EB, Abd Elmageed ZY, Alamodi AA, Selimovic D, Alkhateeb A, Hannig M, Hassan SY, Santourlidis S, Friedlander PL, Haikel Y, Vijaykumar S, Kandil E, Hassan M. El Jamal SM, et al. Cell Div. 2016 Aug 2;11:11. doi: 10.1186/s13008-016-0023-4. eCollection 2016. Cell Div. 2016. PMID: 27486476 Free PMC article.
Interestingly, IFNgamma induced the loss of mitochondrial membrane potential (deltapsim) and increased accumulation of reactive oxygen species (ROS). The cytokine also induced the activation of Janus kinase (JAK)/Signal Transducer and Activator of Transcripti …
Interestingly, IFNgamma induced the loss of mitochondrial membrane potential (deltapsim) and increased accumulation of reactive ox …
Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration.
Schwabe RF, Bataller R, Brenner DA. Schwabe RF, et al. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G949-58. doi: 10.1152/ajpgi.00215.2003. Epub 2003 Jun 26. Am J Physiol Gastrointest Liver Physiol. 2003. PMID: 12829440 Free article.
NF-kappaB activation was sufficient to drive RANTES expression as demonstrated by the strong induction of RANTES in HSCs expressing NF-kappaB-inducing kinase. ...Diphenylene iodonium and N-acetylcysteine inhibited rhRANTES-induced ERK activation and HS …
NF-kappaB activation was sufficient to drive RANTES expression as demonstrated by the strong induction of RANTES in HSCs expre …
Hydrogen peroxide-mediated inhibition of lipopolysaccharide-stimulated inhibitory kappa B kinase activity in rat aortic smooth muscle cells.
Torrie LJ, MacKenzie CJ, Paul A, Plevin R. Torrie LJ, et al. Br J Pharmacol. 2001 Sep;134(2):393-401. doi: 10.1038/sj.bjp.0704259. Br J Pharmacol. 2001. PMID: 11564658 Free PMC article.
In rat aortic smooth muscle cells (RASMC), exposure to lipopolysaccharide (LPS) resulted in NF-kappaB-DNA binding, degradation of IkappaB-alpha, -beta and -epsilon and increased activity of both alpha and beta isoforms of inhibitory kappa B kinase (IKK …
In rat aortic smooth muscle cells (RASMC), exposure to lipopolysaccharide (LPS) resulted in NF-kappaB-DNA binding, degradation …