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2001 1
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11 results

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Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.
Nakano H, Nakajima A, Sakon-Komazawa S, Piao JH, Xue X, Okumura K. Nakano H, et al. Cell Death Differ. 2006 May;13(5):730-7. doi: 10.1038/sj.cdd.4401830. Cell Death Differ. 2006. PMID: 16341124 Review.
Recent studies have indicated that one of the antiapoptotic functions of NF-kappaB is to downregulate JNK activation. Further studies have also revealed that NF-kappaB inhibits JNK activation by suppressing accumulation of reactive
Recent studies have indicated that one of the antiapoptotic functions of NF-kappaB is to downregulate JNK activation. F …
Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.
Wullaert A, Heyninck K, Beyaert R. Wullaert A, et al. Biochem Pharmacol. 2006 Oct 30;72(9):1090-101. doi: 10.1016/j.bcp.2006.07.003. Epub 2006 Aug 24. Biochem Pharmacol. 2006. PMID: 16934229 Review.
However, during the past few years it has become clear that NF-kappaB-mediated inhibition of cell death also involves attenuating TNF-induced activation of c-Jun activating kinase (JNK). ...In this review, we will discuss the various mechanisms by whic …
However, during the past few years it has become clear that NF-kappaB-mediated inhibition of cell death also involves a …
Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance.
Bubici C, Papa S, Dean K, Franzoso G. Bubici C, et al. Oncogene. 2006 Oct 30;25(51):6731-48. doi: 10.1038/sj.onc.1209936. Oncogene. 2006. PMID: 17072325 Review.
Remarkably, new evidence has unveiled the existence of a reciprocal, negative control that NF-kappaB exerts on ROS and JNK activities. This NF-kappaB-imposed restraint on ROS and JNK signaling is crucial for antagonism of PCD elicited by …
Remarkably, new evidence has unveiled the existence of a reciprocal, negative control that NF-kappaB exerts on ROS and JNK
TNF receptor superfamily-induced cell death: redox-dependent execution.
Shen HM, Pervaiz S. Shen HM, et al. FASEB J. 2006 Aug;20(10):1589-98. doi: 10.1096/fj.05-5603rev. FASEB J. 2006. PMID: 16873882 Review.
Recently, some important discoveries have underscored the critical role of ROS in TNFalpha signaling, notably in TNFalpha-mediated activation of nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (c-Jun NH2-terminal kinase, JNK), as w …
Recently, some important discoveries have underscored the critical role of ROS in TNFalpha signaling, notably in TNFalpha-mediated ac …
Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways.
Mi Y, Xiao C, Du Q, Wu W, Qi G, Liu X. Mi Y, et al. Free Radic Biol Med. 2016 Jan;90:230-42. doi: 10.1016/j.freeradbiomed.2015.11.022. Epub 2015 Nov 22. Free Radic Biol Med. 2016. PMID: 26593748
Momordin Ic simultaneously induces autophagy and apoptosis by suppressing the ROS-mediated PI3K/Akt and activating the ROS-related JNK and P38 pathways. Additionally, momordin Ic induces apoptosis by suppressing PI3K/Akt-dependent NF-kappaB pathways an …
Momordin Ic simultaneously induces autophagy and apoptosis by suppressing the ROS-mediated PI3K/Akt and activating the ROS-related …
Carveol alleviates osteoarthritis progression by acting on synovial macrophage polarization transformation: An in vitro and in vivo study.
Chen S, Xu H, He Y, Meng C, Fan Y, Qu Y, Wang Y, Zhou W, Huang X, You H. Chen S, et al. Chem Biol Interact. 2024 Jan 5;387:110781. doi: 10.1016/j.cbi.2023.110781. Epub 2023 Nov 14. Chem Biol Interact. 2024. PMID: 37967808
To investigate the role and regulatory mechanism of Carveol in cartilage and synovial macrophage reprogramming and crosstalk during the development of OA. RAW264.7 mouse macrophage cell line was mainly used to stimulate macrophages to polarization towards M1 and M2 by LPS, …
To investigate the role and regulatory mechanism of Carveol in cartilage and synovial macrophage reprogramming and crosstalk during t …
Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis.
Panzhinskiy E, Ren J, Nair S. Panzhinskiy E, et al. PLoS One. 2013 Oct 18;8(10):e77228. doi: 10.1371/journal.pone.0077228. eCollection 2013. PLoS One. 2013. Retraction in: PLoS One. 2022 Aug 4;17(8):e0272823. doi: 10.1371/journal.pone.0272823. PMID: 24204775 Free PMC article. Retracted.
Treatment of C2C12 myotubes with the ER-stressor tunicamycin resulted in the accumulation of reactive oxygen species (ROS), leading to the activation of protein expression of PTP1B. Furthermore, tunicamycin-induced ROS production activated nuclear translocati …
Treatment of C2C12 myotubes with the ER-stressor tunicamycin resulted in the accumulation of reactive oxygen species (R …
Lobaplatin induces pyroptosis through regulating cIAP1/2, Ripoptosome and ROS in nasopharyngeal carcinoma.
Chen Z, Xu G, Wu D, Wu S, Gong L, Li Z, Luo G, Hu J, Chen J, Huang X, Chen C, Jiang Z, Li X. Chen Z, et al. Biochem Pharmacol. 2020 Jul;177:114023. doi: 10.1016/j.bcp.2020.114023. Epub 2020 May 13. Biochem Pharmacol. 2020. PMID: 32413426
Lobaplatin, as an effective third-generation platinum with fewer adverse reactions and less platinum cross-resistance, has been considered as a good alternative to cisplatin after cisplatin's failure (relapse or metastasis) in the treatment of NPC. ...Importantly, t …
Lobaplatin, as an effective third-generation platinum with fewer adverse reactions and less platinum cross-resistance, has bee …
Hydrogen peroxide-mediated inhibition of lipopolysaccharide-stimulated inhibitory kappa B kinase activity in rat aortic smooth muscle cells.
Torrie LJ, MacKenzie CJ, Paul A, Plevin R. Torrie LJ, et al. Br J Pharmacol. 2001 Sep;134(2):393-401. doi: 10.1038/sj.bjp.0704259. Br J Pharmacol. 2001. PMID: 11564658 Free PMC article.
Expression of dominant-negative (DN)-IKK-alpha, IKK-beta and NF-kappaB-inducing kinase (NIK) abolished LPS-stimulated NF-kappaB reporter activity, suggesting that activation of a NIK/IKK-dependent pathway is indispensable for NF-kappaB ac …
Expression of dominant-negative (DN)-IKK-alpha, IKK-beta and NF-kappaB-inducing kinase (NIK) abolished LPS-stimulated NF
Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration.
Schwabe RF, Bataller R, Brenner DA. Schwabe RF, et al. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G949-58. doi: 10.1152/ajpgi.00215.2003. Epub 2003 Jun 26. Am J Physiol Gastrointest Liver Physiol. 2003. PMID: 12829440 Free article.
NF-kappaB activation was sufficient to drive RANTES expression as demonstrated by the strong induction of RANTES in HSCs expressing NF-kappaB-inducing kinase. ...Diphenylene iodonium and N-acetylcysteine inhibited rhRANTES-induced ERK activation and HS
NF-kappaB activation was sufficient to drive RANTES expression as demonstrated by the strong induction of RANTES in HSCs expre
11 results