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Reconstitution of CD39 in liposomes amplifies nucleoside triphosphate diphosphohydrolase activity and restores thromboregulatory properties.
Haller CA, Cui W, Wen J, Robson SC, Chaikof EL. Haller CA, et al. J Vasc Surg. 2006 Apr;43(4):816-23. doi: 10.1016/j.jvs.2005.11.057. J Vasc Surg. 2006. PMID: 16616242 Free article.
Thus, motivation exists to examine therapeutic antiplatelet formulations that consist of liposomal CD39. METHODS: Full-length human CD39 was produced by using a yeast expression system, purified, and reconstituted within lipid vesicles. ...There was a …
Thus, motivation exists to examine therapeutic antiplatelet formulations that consist of liposomal CD39. METHODS: Full-length …
Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice.
Covarrubias R, Chepurko E, Reynolds A, Huttinger ZM, Huttinger R, Stanfill K, Wheeler DG, Novitskaya T, Robson SC, Dwyer KM, Cowan PJ, Gumina RJ. Covarrubias R, et al. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1809-20. doi: 10.1161/ATVBAHA.116.307374. Epub 2016 Jul 14. Arterioscler Thromb Vasc Biol. 2016. PMID: 27417582 Free PMC article.
OBJECTIVE: Circulating blood cells and endothelial cells express ectonucleoside triphosphate diphosphohydrolase-1 (CD39) and ecto-5'-nucleotidase (CD73). CD39 hydrolyzes extracellular ATP or ADP to AMP. ...FeCl3-induced arterial thrombosis in chimeric mice revealed …
OBJECTIVE: Circulating blood cells and endothelial cells express ectonucleoside triphosphate diphosphohydrolase-1 (CD39) and ecto-5'- …