Redinbo M - Search Results

1

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.

Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S. Wang H, et al. Among authors: redinbo m. Mol Endocrinol. 2008 Apr;22(4):838-57. doi: 10.1210/me.2007-0218. Epub 2007 Dec 20. Mol Endocrinol. 2008. PMID: 18096694 Free PMC article.

2

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

Huang H, Wang H, Sinz M, Zoeckler M, Staudinger J, Redinbo MR, Teotico DG, Locker J, Kalpana GV, Mani S. Huang H, et al. Among authors: redinbo mr. Oncogene. 2007 Jan 11;26(2):258-68. doi: 10.1038/sj.onc.1209788. Epub 2006 Jul 3. Oncogene. 2007. PMID: 16819505

3

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.

Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Chrencik JE, et al. Mol Endocrinol. 2005 May;19(5):1125-34. doi: 10.1210/me.2004-0346. Epub 2005 Feb 10. Mol Endocrinol. 2005. PMID: 15705662

4

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition.

Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR. Xue Y, et al. Mol Endocrinol. 2007 May;21(5):1028-38. doi: 10.1210/me.2006-0323. Epub 2007 Feb 27. Mol Endocrinol. 2007. PMID: 17327420

5

Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.

Wang H, Huang H, Li H, Teotico DG, Sinz M, Baker SD, Staudinger J, Kalpana G, Redinbo MR, Mani S. Wang H, et al. Among authors: redinbo mr. Clin Cancer Res. 2007 Apr 15;13(8):2488-95. doi: 10.1158/1078-0432.CCR-06-1592. Clin Cancer Res. 2007. PMID: 17438109

6

Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.

Biswas A, Mani S, Redinbo MR, Krasowski MD, Li H, Ekins S. Biswas A, et al. Pharm Res. 2009 Aug;26(8):1807-15. doi: 10.1007/s11095-009-9901-7. Epub 2009 May 5. Pharm Res. 2009. PMID: 19415465 Free PMC article. Review.

7

PXR antagonists and implication in drug metabolism.

Mani S, Dou W, Redinbo MR. Mani S, et al. Drug Metab Rev. 2013 Feb;45(1):60-72. doi: 10.3109/03602532.2012.746363. Drug Metab Rev. 2013. PMID: 23330542 Free PMC article. Review.

8

Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR.

Li H, Redinbo MR, Venkatesh M, Ekins S, Chaudhry A, Bloch N, Negassa A, Mukherjee P, Kalpana G, Mani S. Li H, et al. Among authors: redinbo mr. J Biol Chem. 2013 May 10;288(19):13655-68. doi: 10.1074/jbc.M113.455485. Epub 2013 Mar 22. J Biol Chem. 2013. PMID: 23525103 Free PMC article.

9

Regulation of cyp3a gene transcription by the pregnane x receptor.

Goodwin B, Redinbo MR, Kliewer SA. Goodwin B, et al. Annu Rev Pharmacol Toxicol. 2002;42:1-23. doi: 10.1146/annurev.pharmtox.42.111901.111051. Annu Rev Pharmacol Toxicol. 2002. PMID: 11807162 Review.

10

Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.

Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR. Xue Y, et al. Among authors: redinbo mr. Bioorg Med Chem. 2007 Mar 1;15(5):2156-66. doi: 10.1016/j.bmc.2006.12.026. Epub 2006 Dec 20. Bioorg Med Chem. 2007. PMID: 17215127 Free PMC article.

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