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Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors.
Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E. Kathmann M, et al. Among authors: redmer a. Naunyn Schmiedebergs Arch Pharmacol. 2006 Feb;372(5):354-61. doi: 10.1007/s00210-006-0033-x. Epub 2006 Feb 18. Naunyn Schmiedebergs Arch Pharmacol. 2006. PMID: 16489449
Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor.
Schulte K, Steingrüber N, Jergas B, Redmer A, Kurz CM, Buchalla R, Lutz B, Zimmer A, Schlicker E. Schulte K, et al. Among authors: redmer a. Naunyn Schmiedebergs Arch Pharmacol. 2012 Apr;385(4):385-96. doi: 10.1007/s00210-011-0717-8. Epub 2012 Jan 4. Naunyn Schmiedebergs Arch Pharmacol. 2012. PMID: 22215206