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MicroRNA-146a is upregulated by and negatively regulates TLR2 signaling.
Quinn EM, Wang JH, O'Callaghan G, Redmond HP. Quinn EM, et al. Among authors: redmond hp. PLoS One. 2013 Apr 29;8(4):e62232. doi: 10.1371/journal.pone.0062232. Print 2013. PLoS One. 2013. PMID: 23638011 Free PMC article.
The aim of this study was to assess the role of miR-146a in the TLR2 signaling and development of bacterial lipoprotein (BLP) self-tolerance and cross-tolerance to bacteria. ...
The aim of this study was to assess the role of miR-146a in the TLR2 signaling and development of bacterial lipoprotein (BLP) self-to …
Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways.
Coveney AP, Wang W, Kelly J, Liu JH, Blankson S, Wu QD, Redmond HP, Wang JH. Coveney AP, et al. Among authors: redmond hp. Sci Rep. 2015 Sep 2;5:13694. doi: 10.1038/srep13694. Sci Rep. 2015. PMID: 26329314 Free PMC article.
Moreover, Mrp8 tolerisation significantly reduced serum TNF-alpha and IL-6, increased polymorphonuclear neutrophil (PMN) recruitment and accelerated bacterial clearance, thus protecting mice against LPS-induced lethality and cecal ligation and puncture (CLP)-induced polymicrobial …
Moreover, Mrp8 tolerisation significantly reduced serum TNF-alpha and IL-6, increased polymorphonuclear neutrophil (PMN) recruitment and acc …
Activation of the TLR2-mediated downstream signaling pathways NF-κB and MAPK is responsible for B7-H3-augmented inflammatory response during S. pneumoniae infection.
Chen X, Meng X, Foley NM, Shi X, Liu M, Chai Y, Li Y, Redmond HP, Wang J, Wang JH. Chen X, et al. Among authors: redmond hp. J Neuroimmunol. 2017 Sep 15;310:82-90. doi: 10.1016/j.jneuroim.2017.07.002. Epub 2017 Jul 4. J Neuroimmunol. 2017. PMID: 28778451
It has been reported that B7-H3, a costimulatory protein, participates in the development and progression of experimental pneumococcal meningitis by amplifying the TLR2-mediated inflammatory response. This study attempted to clarify the pathway(s) of TLR2 signaling …
It has been reported that B7-H3, a costimulatory protein, participates in the development and progression of experimental pneumococcal menin …
Bacterial lipoprotein-induced tolerance is reversed by overexpression of IRAK-1.
Li CH, Liu J, An M, Redmond HP, Wang JH. Li CH, et al. Among authors: redmond hp. Immunol Cell Biol. 2012 Mar;90(3):314-20. doi: 10.1038/icb.2011.37. Epub 2011 May 3. Immunol Cell Biol. 2012. PMID: 21537341
In this study, we attempted to clarify whether TLR2 and/or IRAK-1 are the key molecules responsible for BLP-induced tolerance. Transfection of HEK293 cells and THP-1 cells with the plasmid encoding TLR2 affected neither BLP tolerisation-induced NF-kappaB deactivatio …
In this study, we attempted to clarify whether TLR2 and/or IRAK-1 are the key molecules responsible for BLP-induced tolerance. Transf …
Bacterial superantigens enhance the in vitro proinflammatory response and in vivo lethality of the TLR2 agonist bacterial lipoprotein.
Kearney DE, Wang W, Redmond HP, Wang JH. Kearney DE, et al. Among authors: redmond hp. J Immunol. 2011 Nov 15;187(10):5363-9. doi: 10.4049/jimmunol.1003747. Epub 2011 Oct 14. J Immunol. 2011. PMID: 22003201 Free article.
The aim of this study was to investigate the relationship between superantigens and the TLR2 agonist bacterial lipoprotein (BLP). Priming of human monocytes or PBMCs with superantigens significantly enhanced proinflammatory cytokine TNF-alpha and IL-6 release in response t …
The aim of this study was to investigate the relationship between superantigens and the TLR2 agonist bacterial lipoprotein (BLP). Pri …
ST2 negatively regulates TLR2 signaling, but is not required for bacterial lipoprotein-induced tolerance.
Liu J, Buckley JM, Redmond HP, Wang JH. Liu J, et al. Among authors: redmond hp. J Immunol. 2010 May 15;184(10):5802-8. doi: 10.4049/jimmunol.0904127. Epub 2010 Apr 16. J Immunol. 2010. PMID: 20400705 Free article.
However, it is undetermined whether ST2 negatively regulates TLR2 signaling and furthermore, whether a TLR2 agonist, bacterial lipoprotein (BLP)-induced tolerance is dependent on ST2. ...Taken together, our results demonstrate that ST2 acts as a negative regulator o …
However, it is undetermined whether ST2 negatively regulates TLR2 signaling and furthermore, whether a TLR2 agonist, bacterial …
NF-κB activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection.
Liu J, Xiang J, Li X, Blankson S, Zhao S, Cai J, Jiang Y, Redmond HP, Wang JH. Liu J, et al. Among authors: redmond hp. Sci Rep. 2017 Jan 12;7:40418. doi: 10.1038/srep40418. Sci Rep. 2017. PMID: 28079153 Free PMC article.
It has been well-documented that BLP tolerance-attenuated proinflammatory cytokine production is associated with suppressed TLR2 signalling pathway; however, the underlying mechanism(s) involved in BLP tolerance-enhanced antimicrobial activity is unclear. ...
It has been well-documented that BLP tolerance-attenuated proinflammatory cytokine production is associated with suppressed TLR2 sign …
B7-H3 augments the inflammatory response and is associated with human sepsis.
Zhang G, Wang J, Kelly J, Gu G, Hou J, Zhou Y, Redmond HP, Wang JH, Zhang X. Zhang G, et al. Among authors: redmond hp. J Immunol. 2010 Sep 15;185(6):3677-84. doi: 10.4049/jimmunol.0904020. Epub 2010 Aug 9. J Immunol. 2010. PMID: 20696859 Free article.
In this paper, we show that, although B7-H3 alone failed to stimulate proinflammatory cytokine release from murine macrophages, it strongly augmented both LPS- and bacterial lipoprotein-induced NF-kappaB activation and inflammatory response. This occurred in both a TLR4- and T …
In this paper, we show that, although B7-H3 alone failed to stimulate proinflammatory cytokine release from murine macrophages, it strongly …
Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression.
Wang JH, Doyle M, Manning BJ, Di Wu Q, Blankson S, Redmond HP. Wang JH, et al. Among authors: redmond hp. J Biol Chem. 2002 Sep 27;277(39):36068-75. doi: 10.1074/jbc.M205584200. Epub 2002 Jul 19. J Biol Chem. 2002. PMID: 12133836 Free article.
More importantly, pretreatment of THP-1 cells with BLP strongly inhibited TLR2 activation in response to subsequent BLP stimulation. In contrast, LPS tolerance did not prevent BLP-induced TLR2 overexpression. These results demonstrate that BLP tolerance develops thr …
More importantly, pretreatment of THP-1 cells with BLP strongly inhibited TLR2 activation in response to subsequent BLP stimulation. …
The utility of plasma circulating cell-free messenger RNA as a biomarker of glioma: a pilot study.
Ita MI, Wang JH, Toulouse A, Lim C, Fanning N, O'Sullivan M, Nolan Y, Kaar GF, Redmond HP. Ita MI, et al. Among authors: redmond hp. Acta Neurochir (Wien). 2022 Mar;164(3):723-735. doi: 10.1007/s00701-021-05014-8. Epub 2021 Oct 13. Acta Neurochir (Wien). 2022. PMID: 34643804 Free PMC article.
Plasma ccfmRNAs and glioma-derived RNA were extracted and profiled. RESULTS: BCL2L1, GZMB, HLA-A, IRF1, MYD88, TLR2, and TP53 genes were significantly over-expressed in glioma patients (p < 0.001, versus control). ...
Plasma ccfmRNAs and glioma-derived RNA were extracted and profiled. RESULTS: BCL2L1, GZMB, HLA-A, IRF1, MYD88, TLR2, and TP53 genes w …
16 results