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Activation of the TLR2-mediated downstream signaling pathways NF-κB and MAPK is responsible for B7-H3-augmented inflammatory response during S. pneumoniae infection.
Chen X, Meng X, Foley NM, Shi X, Liu M, Chai Y, Li Y, Redmond HP, Wang J, Wang JH. Chen X, et al. Among authors: redmond hp. J Neuroimmunol. 2017 Sep 15;310:82-90. doi: 10.1016/j.jneuroim.2017.07.002. Epub 2017 Jul 4. J Neuroimmunol. 2017. PMID: 28778451
It has been reported that B7-H3, a costimulatory protein, participates in the development and progression of experimental pneumococcal meningitis by amplifying the TLR2-mediated inflammatory response. This study attempted to clarify the pathway(s) of TLR2 signaling …
It has been reported that B7-H3, a costimulatory protein, participates in the development and progression of experimental pneumococcal menin …
MicroRNA-146a is upregulated by and negatively regulates TLR2 signaling.
Quinn EM, Wang JH, O'Callaghan G, Redmond HP. Quinn EM, et al. Among authors: redmond hp. PLoS One. 2013 Apr 29;8(4):e62232. doi: 10.1371/journal.pone.0062232. Print 2013. PLoS One. 2013. PMID: 23638011 Free PMC article.
The aim of this study was to assess the role of miR-146a in the TLR2 signaling and development of bacterial lipoprotein (BLP) self-tolerance and cross-tolerance to bacteria. ...
The aim of this study was to assess the role of miR-146a in the TLR2 signaling and development of bacterial lipoprotein (BLP) self-to …
Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways.
Coveney AP, Wang W, Kelly J, Liu JH, Blankson S, Wu QD, Redmond HP, Wang JH. Coveney AP, et al. Among authors: redmond hp. Sci Rep. 2015 Sep 2;5:13694. doi: 10.1038/srep13694. Sci Rep. 2015. PMID: 26329314 Free PMC article.
In addition to TLR4, TLR2 also contributed to Mrp8-induced inflammatory response and tolerance. Down-regulation of phosphorylated p38 by Mrp8 pre-stimulation was predominantly responsible for the intracellular mechanism of Mrp8-induced tolerance. ...
In addition to TLR4, TLR2 also contributed to Mrp8-induced inflammatory response and tolerance. Down-regulation of phosphorylated p38 …
B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage via Amplifying NF-κB p65 and MAPK p38 Activation during Experimental Pneumococcal Meningitis.
Chen X, Li Y, Blankson S, Liu M, Huang D, Redmond HP, Huang J, Wang JH, Wang J. Chen X, et al. Among authors: redmond hp. PLoS One. 2017 Jan 31;12(1):e0171146. doi: 10.1371/journal.pone.0171146. eCollection 2017. PLoS One. 2017. PMID: 28141831 Free PMC article.
Administration of B7-H3 did not augment expression of TLR2 and other TLR2 upstream components, but led to an enhanced formation of MyD88-IRAK immunocomplex in the brain of S. pneumoniae-infected mice. Furthermore, B7-H3 substantially augmented S. pneumoniae-induced …
Administration of B7-H3 did not augment expression of TLR2 and other TLR2 upstream components, but led to an enhanced formatio …
NF-κB activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection.
Liu J, Xiang J, Li X, Blankson S, Zhao S, Cai J, Jiang Y, Redmond HP, Wang JH. Liu J, et al. Among authors: redmond hp. Sci Rep. 2017 Jan 12;7:40418. doi: 10.1038/srep40418. Sci Rep. 2017. PMID: 28079153 Free PMC article.
It has been well-documented that BLP tolerance-attenuated proinflammatory cytokine production is associated with suppressed TLR2 signalling pathway; however, the underlying mechanism(s) involved in BLP tolerance-enhanced antimicrobial activity is unclear. ...
It has been well-documented that BLP tolerance-attenuated proinflammatory cytokine production is associated with suppressed TLR2 sign …
Bacterial superantigens enhance the in vitro proinflammatory response and in vivo lethality of the TLR2 agonist bacterial lipoprotein.
Kearney DE, Wang W, Redmond HP, Wang JH. Kearney DE, et al. Among authors: redmond hp. J Immunol. 2011 Nov 15;187(10):5363-9. doi: 10.4049/jimmunol.1003747. Epub 2011 Oct 14. J Immunol. 2011. PMID: 22003201 Free article.
The aim of this study was to investigate the relationship between superantigens and the TLR2 agonist bacterial lipoprotein (BLP). ...
The aim of this study was to investigate the relationship between superantigens and the TLR2 agonist bacterial lipoprotein (BLP). ...
ST2 negatively regulates TLR2 signaling, but is not required for bacterial lipoprotein-induced tolerance.
Liu J, Buckley JM, Redmond HP, Wang JH. Liu J, et al. Among authors: redmond hp. J Immunol. 2010 May 15;184(10):5802-8. doi: 10.4049/jimmunol.0904127. Epub 2010 Apr 16. J Immunol. 2010. PMID: 20400705 Free article.
However, it is undetermined whether ST2 negatively regulates TLR2 signaling and furthermore, whether a TLR2 agonist, bacterial lipoprotein (BLP)-induced tolerance is dependent on ST2. ...Taken together, our results demonstrate that ST2 acts as a negative regulator o …
However, it is undetermined whether ST2 negatively regulates TLR2 signaling and furthermore, whether a TLR2 agonist, bacterial …
B7-H3 augments the inflammatory response and is associated with human sepsis.
Zhang G, Wang J, Kelly J, Gu G, Hou J, Zhou Y, Redmond HP, Wang JH, Zhang X. Zhang G, et al. Among authors: redmond hp. J Immunol. 2010 Sep 15;185(6):3677-84. doi: 10.4049/jimmunol.0904020. Epub 2010 Aug 9. J Immunol. 2010. PMID: 20696859 Free article.
This occurred in both a TLR4- and TLR2-dependent manner. Blockage of B7-H3 in vivo attenuated LPS-induced proinflammatory cytokine release and endotoxic shock-related lethality. ...
This occurred in both a TLR4- and TLR2-dependent manner. Blockage of B7-H3 in vivo attenuated LPS-induced proinflammatory cytokine re …
B7-H3 participates in the development of experimental pneumococcal meningitis by augmentation of the inflammatory response via a TLR2-dependent mechanism.
Chen X, Quinn EM, Ni H, Wang J, Blankson S, Redmond HP, Wang JH, Feng X. Chen X, et al. Among authors: redmond hp. J Immunol. 2012 Jul 1;189(1):347-55. doi: 10.4049/jimmunol.1103715. Epub 2012 Jun 1. J Immunol. 2012. PMID: 22661093 Free article.
These B7-H3-associated in vitro and in vivo effects appeared to be dependent on TLR2 signaling, as B7-H3 almost completely lost its amplifying actions in both TLR2-deficient microglial cells and TLR2-deficient mice. ...
These B7-H3-associated in vitro and in vivo effects appeared to be dependent on TLR2 signaling, as B7-H3 almost completely lost its a …
Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression.
Wang JH, Doyle M, Manning BJ, Di Wu Q, Blankson S, Redmond HP. Wang JH, et al. Among authors: redmond hp. J Biol Chem. 2002 Sep 27;277(39):36068-75. doi: 10.1074/jbc.M205584200. Epub 2002 Jul 19. J Biol Chem. 2002. PMID: 12133836 Free article.
However, BLP strongly enhanced TLR2 expression in non-tolerized THP-1 cells, whereas LPS stimulation had no effect. Furthermore, a specific TLR2 blocking monoclonal antibody (2392) attenuated BLP-induced, but not LPS-induced, tumor necrosis factor-alpha and interleu …
However, BLP strongly enhanced TLR2 expression in non-tolerized THP-1 cells, whereas LPS stimulation had no effect. Furthermore, a sp …
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