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Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?
Obeid R, Holzgreve W, Pietrzik K. Obeid R, et al. J Perinat Med. 2013 Sep 1;41(5):469-83. doi: 10.1515/jpm-2012-0256. J Perinat Med. 2013. PMID: 23482308 Free article. Review.
Supplemental folate [folic acid (FA) or 5-methyltetrahydrofolate (5-methylTHF)] can effectively increase folate concentrations to the level that is considered to be protective. FA is a synthetic compound that has no biological functions unless it is reduce
Supplemental folate [folic acid (FA) or 5-methyltetrahydrofolate (5-methylTHF)] can effectively increase folate concentrations …
Homocysteine lowering interventions for peripheral arterial disease and bypass grafts.
Andras A, Stansby G, Hansrani M. Andras A, et al. Cochrane Database Syst Rev. 2013 Jul 19;2013(7):CD003285. doi: 10.1002/14651858.CD003285.pub2. Cochrane Database Syst Rev. 2013. PMID: 23881650 Free PMC article. Review.
Treatment to lower homocysteine levels has been shown to be both effective and cheap in healthy volunteers. However, the impact of reducing homocysteine levels on the progression of atherosclerosis and patency of the vessels after treatment for atherosclerosi …
Treatment to lower homocysteine levels has been shown to be both effective and cheap in healthy volunteers. However, the impact of …
Functional methionine synthase deficiency (cblE and cblG): clinical and biochemical heterogeneity.
Watkins D, Rosenblatt DS. Watkins D, et al. Am J Med Genet. 1989 Nov;34(3):427-34. doi: 10.1002/ajmg.1320340320. Am J Med Genet. 1989. PMID: 2688421 Review.
Fibroblasts from patients with cblE (5 patients) and cblG (6 patients) all showed decreased intracellular levels of methylcobalamin (MeCbl) and decreased incorporation of label from 5-methyltetrahydrofolate into macromolecules, suggesting decreased activity o …
Fibroblasts from patients with cblE (5 patients) and cblG (6 patients) all showed decreased intracellular levels of methylcobalamin ( …
The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.
Zhao R, Aluri S, Goldman ID. Zhao R, et al. Mol Aspects Med. 2017 Feb;53:57-72. doi: 10.1016/j.mam.2016.09.002. Epub 2016 Sep 21. Mol Aspects Med. 2017. PMID: 27664775 Free PMC article. Review.
This paper reviews the current understanding of the functional and structural properties and regulation of PCFT, an electrogenic proton symporter, and contrasts PCFT properties with those of the reduced folate carrier (RFC), an organic anion antiporter, that is the major r …
This paper reviews the current understanding of the functional and structural properties and regulation of PCFT, an electrogenic proton symp …
Homocysteine and neural tube defects.
Mills JL, Scott JM, Kirke PN, McPartlin JM, Conley MR, Weir DG, Molloy AM, Lee YJ. Mills JL, et al. J Nutr. 1996 Mar;126(3):756S-760S. doi: 10.1093/jn/126.suppl_3.756S. J Nutr. 1996. PMID: 8598561 Review.
Our recent work demonstrates that homocysteine metabolism is likely to be the critical pathway affected by folic acid. We have demonstrated significantly higher homocysteine levels in women carrying affected fetuses than in control women. These findings indicate that one o …
Our recent work demonstrates that homocysteine metabolism is likely to be the critical pathway affected by folic acid. We have demonstrated …
Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy.
Valik D, Radina M, Sterba J, Vojtesek B. Valik D, et al. Pharmacogenomics. 2004 Dec;5(8):1151-62. doi: 10.1517/14622416.5.8.1151. Pharmacogenomics. 2004. PMID: 15584881 Review.
For decades it has been well known that elevated levels of homocysteine are harmful to humans on the basis of clinical observations derived from classical model diseases, such as inherited metabolic disorders. ...Homocysteine lies in a metabolic checkpoint that interconnec …
For decades it has been well known that elevated levels of homocysteine are harmful to humans on the basis of clinical observations d …
Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate.
Nzila A, Okombo J, Molloy AM. Nzila A, et al. J Antimicrob Chemother. 2014 Feb;69(2):323-30. doi: 10.1093/jac/dkt394. Epub 2013 Oct 14. J Antimicrob Chemother. 2014. PMID: 24126794 Review.
This is based on the use of the antifolate sulfadoxine/pyrimethamine, taken at specified intervals during pregnancy, and reports show that this approach reduces the malaria burden in pregnancy. Pregnancy is also associated with the risk of neural tube defects (NTDs), espec …
This is based on the use of the antifolate sulfadoxine/pyrimethamine, taken at specified intervals during pregnancy, and reports show that t …
Neural tube defects and a disturbed folate dependent homocysteine metabolism.
van der Put NM, Blom HJ. van der Put NM, et al. Eur J Obstet Gynecol Reprod Biol. 2000 Sep;92(1):57-61. doi: 10.1016/s0301-2115(00)00426-7. Eur J Obstet Gynecol Reprod Biol. 2000. PMID: 10986435 Review.
Folate administration substantially reduces the risk on neural tube defects (NTD). The interest for a disturbed homocysteine (Hcy) metabolism in relation to NTD was raised by the observation of elevated blood Hcy levels in mothers of a NTD child. ...The C677T …
Folate administration substantially reduces the risk on neural tube defects (NTD). The interest for a disturbed homocysteine (Hcy) me …