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Inhibiting epigenetic enzymes to improve atherogenic macrophage functions.
Van den Bossche J, Neele AE, Hoeksema MA, de Heij F, Boshuizen MC, van der Velden S, de Boer VC, Reedquist KA, de Winther MP. Van den Bossche J, et al. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):396-402. doi: 10.1016/j.bbrc.2014.11.029. Epub 2014 Nov 18. Biochem Biophys Res Commun. 2014. PMID: 25446073
Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes.
Tang MW, Malvar Fernández B, Newsom SP, van Buul JD, Radstake TRDJ, Baeten DL, Tak PP, Reedquist KA, García S. Tang MW, et al. Among authors: reedquist ka. Rheumatology (Oxford). 2018 May 1;57(5):909-920. doi: 10.1093/rheumatology/kex511. Rheumatology (Oxford). 2018. PMID: 29471421
Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis.
Garcia S, Hartkamp LM, Malvar-Fernandez B, van Es IE, Lin H, Wong J, Long L, Zanghi JA, Rankin AL, Masteller EL, Wong BR, Radstake TR, Tak PP, Reedquist KA. Garcia S, et al. Arthritis Res Ther. 2016 Mar 31;18:75. doi: 10.1186/s13075-016-0973-6. Arthritis Res Ther. 2016. PMID: 27036883 Free PMC article.
Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation.
Angiolilli C, Kabala PA, Grabiec AM, Rossato M, Lai WS, Fossati G, Mascagni P, Steinkühler C, Blackshear PJ, Reedquist KA, Baeten DL, Radstake TRDJ. Angiolilli C, et al. Among authors: reedquist ka. Arthritis Res Ther. 2018 Jul 20;20(1):148. doi: 10.1186/s13075-018-1638-4. Arthritis Res Ther. 2018. PMID: 30029685 Free PMC article.
The ascent of acetylation in the epigenetics of rheumatoid arthritis.
Grabiec AM, Reedquist KA. Grabiec AM, et al. Nat Rev Rheumatol. 2013 May;9(5):311-8. doi: 10.1038/nrrheum.2013.17. Epub 2013 Feb 26. Nat Rev Rheumatol. 2013. PMID: 23439035 Review.
The acetyl code in rheumatoid arthritis and other rheumatic diseases.
Angiolilli C, Baeten DL, Radstake TR, Reedquist KA. Angiolilli C, et al. Epigenomics. 2017 Apr;9(4):447-461. doi: 10.2217/epi-2016-0136. Epub 2017 Jan 19. Epigenomics. 2017. PMID: 28102705 Review.
Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay.
Grabiec AM, Korchynskyi O, Tak PP, Reedquist KA. Grabiec AM, et al. Ann Rheum Dis. 2012 Mar;71(3):424-31. doi: 10.1136/ard.2011.154211. Epub 2011 Sep 27. Ann Rheum Dis. 2012. PMID: 21953341 Free PMC article.
Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes.
Kabala PA, Angiolilli C, Yeremenko N, Grabiec AM, Giovannone B, Pots D, Radstake TR, Baeten D, Reedquist KA. Kabala PA, et al. Among authors: reedquist ka. Arthritis Res Ther. 2017 Sep 18;19(1):207. doi: 10.1186/s13075-017-1386-x. Arthritis Res Ther. 2017. PMID: 28923079 Free PMC article.
The prolactin receptor is expressed in rheumatoid arthritis and psoriatic arthritis synovial tissue and contributes to macrophage activation.
Tang MW, Reedquist KA, Garcia S, Fernandez BM, Codullo V, Vieira-Sousa E, Goffin V, Reuwer AQ, Twickler MT, Gerlag DM, Tak PP. Tang MW, et al. Rheumatology (Oxford). 2016 Dec;55(12):2248-2259. doi: 10.1093/rheumatology/kew316. Epub 2016 Sep 10. Rheumatology (Oxford). 2016. PMID: 27616146 Free PMC article.
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