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The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects.
Attardi BJ, Hild SA, Koduri S, Pham T, Pessaint L, Engbring J, Till B, Gropp D, Semon A, Reel JR. Attardi BJ, et al. Among authors: Reel JR. J Steroid Biochem Mol Biol. 2010 Oct;122(4):212-8. doi: 10.1016/j.jsbmb.2010.06.009. Epub 2010 Jun 25. J Steroid Biochem Mol Biol. 2010. PMID: 20599615 Free PMC article.
Dimethandrolone (7alpha,11beta-dimethyl-19-nortestosterone) and 11beta-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase.
Attardi BJ, Pham TC, Radler LC, Burgenson J, Hild SA, Reel JR. Attardi BJ, et al. Among authors: Reel JR. J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):214-22. doi: 10.1016/j.jsbmb.2007.11.009. J Steroid Biochem Mol Biol. 2008. PMID: 18555683 Free PMC article.
Acute adverse effects of the indenopyridine CDB-4022 on the ultrastructure of sertoli cells, spermatocytes, and spermatids in rat testes: comparison to the known sertoli cell toxicant Di-n-pentylphthalate (DPP).
Hild SA, Reel JR, Dykstra MJ, Mann PC, Marshall GR. Hild SA, et al. Among authors: Reel JR. J Androl. 2007 Jul-Aug;28(4):621-9. doi: 10.2164/jandrol.106.002295. Epub 2007 Apr 4. J Androl. 2007. PMID: 17409460 Free article.
Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis).
Hild SA, Marshall GR, Attardi BJ, Hess RA, Schlatt S, Simorangkir DR, Ramaswamy S, Koduri S, Reel JR, Plant TM. Hild SA, et al. Among authors: Reel JR. Endocrinology. 2007 Apr;148(4):1784-96. doi: 10.1210/en.2006-1487. Epub 2007 Jan 11. Endocrinology. 2007. PMID: 17218411
In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone.
Attardi BJ, Burgenson J, Hild SA, Reel JR. Attardi BJ, et al. Among authors: Reel JR. J Steroid Biochem Mol Biol. 2004 Mar;88(3):277-88. doi: 10.1016/j.jsbmb.2003.12.004. J Steroid Biochem Mol Biol. 2004. PMID: 15120421
CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914.
Attardi BJ, Burgenson J, Hild SA, Reel JR, Blye RP. Attardi BJ, et al. Among authors: Reel JR. Mol Cell Endocrinol. 2002 Feb 25;188(1-2):111-23. doi: 10.1016/s0303-7207(01)00743-2. Mol Cell Endocrinol. 2002. PMID: 11911951
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