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Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells.
Fujino H, Seira N, Kurata N, Araki Y, Nakamura H, Regan JW, Murayama T. Fujino H, et al. Among authors: regan jw. Eur J Pharmacol. 2015 Dec 5;768:149-59. doi: 10.1016/j.ejphar.2015.10.044. Epub 2015 Oct 28. Eur J Pharmacol. 2015. PMID: 26518053
Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells.
Yoshida K, Fujino H, Otake S, Seira N, Regan JW, Murayama T. Yoshida K, et al. Among authors: regan jw. Eur J Pharmacol. 2013 Oct 15;718(1-3):408-17. doi: 10.1016/j.ejphar.2013.08.002. Epub 2013 Aug 22. Eur J Pharmacol. 2013. PMID: 23973650
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