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Regulating the regulator: post-translational modification of RAS.
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR. Ahearn IM, et al. Nat Rev Mol Cell Biol. 2011 Dec 22;13(1):39-51. doi: 10.1038/nrm3255. Nat Rev Mol Cell Biol. 2011. PMID: 22189424 Free PMC article. Review.
The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which regulate the activation state of RAS without covalently modifying it. By contrast, post-translational …
The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins ( …
Regulation of RAS oncogenicity by acetylation.
Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Yang MH, et al. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10843-8. doi: 10.1073/pnas.1201487109. Epub 2012 Jun 18. Proc Natl Acad Sci U S A. 2012. PMID: 22711838 Free PMC article.
Members of the RAS small GTPase family regulate cellular responses to extracellular stimuli by mediating the flux through downstream signal transduction cascades. ...These data suggest that lysine acetylation is a negative regulatory modification on RAS …
Members of the RAS small GTPase family regulate cellular responses to extracellular stimuli by mediating the flux through down …
HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS.
Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM. Yang MH, et al. Mol Cancer Res. 2013 Sep;11(9):1072-7. doi: 10.1158/1541-7786.MCR-13-0040-T. Epub 2013 May 30. Mol Cancer Res. 2013. PMID: 23723075 Free PMC article.
One potential strategy for overcoming the deleterious effects of mutant K-RAS is to alter its posttranslational modification. Although therapies targeting farnesylation have been explored, and have ultimately failed, the therapeutic potential of targeting other modi …
One potential strategy for overcoming the deleterious effects of mutant K-RAS is to alter its posttranslational modification. …