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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1990 2
1992 1
1993 2
1994 1
1995 2
1996 7
1997 10
1998 8
1999 12
2000 18
2001 15
2002 12
2003 10
2004 5
2005 10
2006 3
2007 7
2008 8
2009 11
2010 7
2011 6
2012 6
2013 13
2014 8
2015 6
2016 5
2017 5
2018 4
2019 3
2020 2
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196 results
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Page 1
Negative Regulation of Cytokine Signaling in Immunity.
Yoshimura A, Ito M, Chikuma S, Akanuma T, Nakatsukasa H. Yoshimura A, et al. Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7):a028571. doi: 10.1101/cshperspect.a028571. Cold Spring Harb Perspect Biol. 2018. PMID: 28716890 Free PMC article. Review.
These include the suppressors of cytokine signaling (SOCS) family of proteins, which represent a main negative regulation mechanism for the JAK-STAT pathway. Cytokine-inducible Src homology 2 (SH2)-containing protein (CIS), SOCS1, and SOC …
These include the suppressors of cytokine signaling (SOCS) family of proteins, which represent a main negative regul
Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases.
Hanada T, Kinjyo I, Inagaki-Ohara K, Yoshimura A. Hanada T, et al. Rev Physiol Biochem Pharmacol. 2003;149:72-86. doi: 10.1007/s10254-003-0015-z. Epub 2003 Mar 29. Rev Physiol Biochem Pharmacol. 2003. PMID: 12687406 Review.
The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that …
The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of int …
Understanding SOCS protein specificity.
Linossi EM, Calleja DJ, Nicholson SE. Linossi EM, et al. Growth Factors. 2018 Aug;36(3-4):104-117. doi: 10.1080/08977194.2018.1518324. Epub 2018 Oct 15. Growth Factors. 2018. PMID: 30318950 Review.
Cytokine signalling is predominantly executed by intracellular proteins known as the Janus kinases (JAKs) and the signal transducers and activators of transcriptions (STATs). ...This is highlighted by the intricate role of the suppressor of cytokine
Cytokine signalling is predominantly executed by intracellular proteins known as the Janus kinases (JAKs) and the signal
[Regulation of cytokine and toll-like receptor signaling by SOCS family genes].
Takagi H, Sanada T, Minoda Y, Yoshimura A. Takagi H, et al. Nihon Rinsho. 2004 Dec;62(12):2189-96. Nihon Rinsho. 2004. PMID: 15597784 Review. Japanese.
Regulation of TLR signaling is a key step for inflammation, septic shock and innate/adaptive immunity. TLR signaling is shown to be regulated by cytokines, such as interferon-gamma (positive) and interleukin-10 and IL-4 (negative). However, mole
Regulation of TLR signaling is a key step for inflammation, septic shock and innate/adaptive immunity. TLR signaling is
Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy.
Chikuma S, Kanamori M, Mise-Omata S, Yoshimura A. Chikuma S, et al. Cancer Sci. 2017 Apr;108(4):574-580. doi: 10.1111/cas.13194. Epub 2017 Apr 19. Cancer Sci. 2017. PMID: 28188673 Free PMC article. Review.
The cytokine interferon-γ (IFNγ) plays an important role in anti-tumor immunity by activating cytotoxic T cells (CTLs). Most cytokines use the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, and the suppressors of cytoki
The cytokine interferon-γ (IFNγ) plays an important role in anti-tumor immunity by activating cytotoxic T cells (CTLs). Most cytok
Negative regulation of cytokine signaling.
Yoshimura A. Yoshimura A. Clin Rev Allergy Immunol. 2005 Jun;28(3):205-20. doi: 10.1385/CRIAI:28:3:205. Clin Rev Allergy Immunol. 2005. PMID: 16129905 Review.
The cytokine inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis …
The cytokine inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family
Negative regulation of cytokine signaling and immune responses by SOCS proteins.
Yoshimura A, Nishinakamura H, Matsumura Y, Hanada T. Yoshimura A, et al. Arthritis Res Ther. 2005;7(3):100-10. doi: 10.1186/ar1741. Epub 2005 Mar 30. Arthritis Res Ther. 2005. PMID: 15899058 Free PMC article. Review.
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of …
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytoki
Regulation of TLR signaling and inflammation by SOCS family proteins.
Yoshimura A, Ohishi HM, Aki D, Hanada T. Yoshimura A, et al. J Leukoc Biol. 2004 Mar;75(3):422-7. doi: 10.1189/jlb.0403194. Epub 2004 Jan 14. J Leukoc Biol. 2004. PMID: 14726494 Review.
The cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including …
The cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are a family
SOCS2: physiological and pathological functions.
Letellier E, Haan S. Letellier E, et al. Front Biosci (Elite Ed). 2016 Jan 1;8:189-204. Front Biosci (Elite Ed). 2016. PMID: 26709655 Free article. Review.
Suppressors of cytokine signalling (SOCS) proteins are modulators of cytokine and growth factor signalling whose aberrant regulation has been linked to a variety of inflammatory and neoplastic diseases. ...At least some of the family memb …
Suppressors of cytokine signalling (SOCS) proteins are modulators of cytokine and growth factor signalling whose …
Negative regulation of cytokine signaling pathways.
Yasukawa H, Sasaki A, Yoshimura A. Yasukawa H, et al. Annu Rev Immunol. 2000;18:143-64. doi: 10.1146/annurev.immunol.18.1.143. Annu Rev Immunol. 2000. PMID: 10837055 Review.
The CIS family of proteins (also referred to as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. ...Therefore, these CIS family members seem to function i …
The CIS family of proteins (also referred to as the SOCS or SSI family) has been implicated in the regulation of …
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