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Regulation of trafficking of activated TrkA is critical for NGF-mediated functions.
Yu T, Calvo L, Anta B, López-Benito S, Southon E, Chao MV, Tessarollo L, Arévalo JC. Yu T, et al. Traffic. 2011 Apr;12(4):521-34. doi: 10.1111/j.1600-0854.2010.01156.x. Epub 2011 Feb 1. Traffic. 2011. PMID: 21199218 Free PMC article.
Proper TrkA trafficking and sorting are crucial events as alteration of these processes hinders NGF-mediated functions. However, it is not fully known which proteins are involved in the trafficking and sorting of TrkA. Here we repo …
Proper TrkA trafficking and sorting are crucial events as alteration of these processes hinders NGF-mediated
In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA.
Yu T, Calvo L, Anta B, López-Benito S, López-Bellido R, Vicente-García C, Tessarollo L, Rodriguez RE, Arévalo JC. Yu T, et al. J Neurosci. 2014 Apr 23;34(17):6098-106. doi: 10.1523/JNEUROSCI.4271-13.2014. J Neurosci. 2014. PMID: 24760869 Free PMC article.
Trk neurotrophin receptor ubiquitination in response to ligand activation regulates signaling, trafficking, and degradation of the receptors. ...Moreover, the mutant mice show enhanced sensitivity to thermal and inflammatory pain. Our results indicate that th …
Trk neurotrophin receptor ubiquitination in response to ligand activation regulates signaling, trafficking, and degrada …
NGF and its receptor system: a new dimension in the pathogenesis of psoriasis and psoriatic arthritis.
Raychaudhuri SK, Raychaudhuri SP. Raychaudhuri SK, et al. Ann N Y Acad Sci. 2009 Sep;1173:470-7. doi: 10.1111/j.1749-6632.2009.04652.x. Ann N Y Acad Sci. 2009. PMID: 19758188
Recent evidence implicates NGF as a key mediator of inflammation and pain. NGF influences an inflammatory reaction by regulating neuropeptides, angiogenesis, cell trafficking molecules, and T cell activation. All of these functions of …
Recent evidence implicates NGF as a key mediator of inflammation and pain. NGF influences an inflammatory reaction by regul