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Direct spatial control of Epac1 by cyclic AMP.
Ponsioen B, Gloerich M, Ritsma L, Rehmann H, Bos JL, Jalink K. Ponsioen B, et al. Among authors: rehmann h. Mol Cell Biol. 2009 May;29(10):2521-31. doi: 10.1128/MCB.01630-08. Epub 2009 Mar 9. Mol Cell Biol. 2009. PMID: 19273589 Free PMC article.
The role of Rap1 in integrin-mediated cell adhesion.
Bos JL, de Bruyn K, Enserink J, Kuiperij B, Rangarajan S, Rehmann H, Riedl J, de Rooij J, van Mansfeld F, Zwartkruis F. Bos JL, et al. Among authors: rehmann h. Biochem Soc Trans. 2003 Feb;31(Pt 1):83-6. doi: 10.1042/bst0310083. Biochem Soc Trans. 2003. PMID: 12546659 Review.
Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.
Rehmann H, Rueppel A, Bos JL, Wittinghofer A. Rehmann H, et al. J Biol Chem. 2003 Jun 27;278(26):23508-14. doi: 10.1074/jbc.M301680200. Epub 2003 Apr 21. J Biol Chem. 2003. PMID: 12707263
Epac is inhibited by an intramolecular interaction between the cAMP-binding domain and the catalytic region in the absence of cAMP. cAMP binding is proposed to induce a conformational change, which allows a LID, an alpha-helix at the C-terminal end of the cAMP-binding site, to co …
Epac is inhibited by an intramolecular interaction between the cAMP-binding domain and the catalytic region in the absence of cAMP. cAMP bin …
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