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The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus.
Reichard P, Nilsson BY, Rosenqvist U. Reichard P, et al. N Engl J Med. 1993 Jul 29;329(5):304-9. doi: 10.1056/NEJM199307293290502. N Engl J Med. 1993. PMID: 8147960 Clinical Trial.
Visual acuity decreased in 6 patients receiving intensified treatment (14 percent) and in 18 receiving standard treatment (35 percent) (P = 0.02). ...No patient in the intensified-treatment group had nephropathy with subnormal glomerular filtration rates, as compared with …
Visual acuity decreased in 6 patients receiving intensified treatment (14 percent) and in 18 receiving standard treatment (35 percent) (P
Early atherosclerosis is retarded by improved long-term blood glucose control in patients with IDDM.
Jensen-Urstad KJ, Reichard PG, Rosfors JS, Lindblad LE, Jensen-Urstad MT. Jensen-Urstad KJ, et al. Diabetes. 1996 Sep;45(9):1253-8. doi: 10.2337/diab.45.9.1253. Diabetes. 1996. PMID: 8772731 Clinical Trial.
The patients in the ST group had stiffer arteries (P = 0.011) and thicker intima-media in the left common carotid artery (P = 0.009) than those in the ICT group. Patients with lower HbA1c generally had better endothelial function (P = 0.028) and less stiff ar …
The patients in the ST group had stiffer arteries (P = 0.011) and thicker intima-media in the left common carotid artery (P = …
Influence of glucose control, lipoproteins, and haemostasis function on brachial endothelial reactivity and carotid intima-media area, stiffness and diameter in Type 1 diabetes mellitus patients.
Johansson J, Reichard P, Jensen-Urstad K, Rosfors S, Jensen-Urstad M. Johansson J, et al. Eur J Clin Invest. 2003 Jun;33(6):472-9. doi: 10.1046/j.1365-2362.2003.01126.x. Eur J Clin Invest. 2003. PMID: 12795643
Decreased heart rate variability in patients with type 1 diabetes mellitus is related to arterial wall stiffness.
Jensen-Urstad K, Reichard P, Jensen-Urstad M. Jensen-Urstad K, et al. J Intern Med. 1999 Jan;245(1):57-61. doi: 10.1046/j.1365-2796.1999.00402.x. J Intern Med. 1999. PMID: 10095817
RESULTS: Patients with stiffer arteries had lower HRV in all spectral bands (r = -0.32 to -0.40, P = 0.06-0.001). This relation remained on correcting for age. All spectral parameters of HRV correlated with the mean HbA1c from 10 years of study (r = -0.37 to -0.40, P
RESULTS: Patients with stiffer arteries had lower HRV in all spectral bands (r = -0.32 to -0.40, P = 0.06-0.001). This relation remai …
Autonomic neuropathy--a complication less pronounced in patients with Type 1 diabetes mellitus who have lower blood glucose levels.
Reichard P, Jensen-Urstad K, Ericsson M, Jensen-Urstad M, Lindblad LE. Reichard P, et al. Diabet Med. 2000 Dec;17(12):860-6. doi: 10.1046/j.1464-5491.2000.00398.x. Diabet Med. 2000. PMID: 11168329 Clinical Trial.
Blood glucose levels (mean of 29 HbA1c values) during the 10 years were lower in the patients from the ICT group (7.2 (0.6) vs. 8.3 (1.0)%, P = 0.001). RESULTS: Heart rate variability (HRV) in the high frequency range (P = 0.034), the expiration-inspiration ratio ( …
Blood glucose levels (mean of 29 HbA1c values) during the 10 years were lower in the patients from the ICT group (7.2 (0.6) vs. 8.3 (1.0)%, …
Intensified conventional insulin treatment retards the microvascular complications of insulin-dependent diabetes mellitus (IDDM): the Stockholm Diabetes Intervention Study (SDIS) after 5 years.
Reichard P, Berglund B, Britz A, Cars I, Nilsson BY, Rosenqvist U. Reichard P, et al. J Intern Med. 1991 Aug;230(2):101-8. doi: 10.1111/j.1365-2796.1991.tb00415.x. J Intern Med. 1991. PMID: 1865159 Clinical Trial.
Retinopathy increased in both groups (P less than 0.001), but after 5 years it was worse in the RT group (P less than 0.05). ...The increases in retinopathy (P less than 0.01), nephropathy (P less than 0.01) and neuropathy (P less than 0.001) we …
Retinopathy increased in both groups (P less than 0.001), but after 5 years it was worse in the RT group (P less than 0.05). . …
Risk factors for progression of microvascular complications in the Stockholm Diabetes Intervention Study (SDIS).
Reichard P. Reichard P. Diabetes Res Clin Pract. 1992 May;16(2):151-6. doi: 10.1016/0168-8227(92)90087-8. Diabetes Res Clin Pract. 1992. PMID: 1600854
In multivariate analyses the mean HbA1c level (14 values during 6-60 months) was significantly correlated with albumin excretion level (P less than 0.01), retinopathy (P less than 0.001), motoric and sensoric nerve conduction velocities (P less than 0.01), th …
In multivariate analyses the mean HbA1c level (14 values during 6-60 months) was significantly correlated with albumin excretion level (P
Intensified conventional insulin treatment and neuropsychological impairment.
Reichard P, Britz A, Rosenqvist U. Reichard P, et al. BMJ. 1991 Dec 7;303(6815):1439-42. doi: 10.1136/bmj.303.6815.1439. BMJ. 1991. PMID: 1773148 Free PMC article. Clinical Trial.
RESULTS: Mean glycated haemoglobin concentration during the study was 7.2% (SE 0.1%) with intensified conventional treatment and 8.7 (0.1%) with standard treatment (p less than 0.001). During five years 34 (77%, 95% confidence interval 53% to 100%) of the patients given in …
RESULTS: Mean glycated haemoglobin concentration during the study was 7.2% (SE 0.1%) with intensified conventional treatment and 8.7 (0.1%) …
Changes in conceptions and attitudes during five years of intensified conventional insulin treatment in the Stockholm Diabetes Intervention Study (SDIS).
Reichard P, Toomingas B, Rosenqvist U. Reichard P, et al. Diabetes Educ. 1994 Nov-Dec;20(6):503-8. doi: 10.1177/014572179402000607. Diabetes Educ. 1994. PMID: 7851263 Clinical Trial.
A risk-benefit assessment of conventional versus intensive insulin therapy.
Reichard P. Reichard P. Drug Saf. 1994 Mar;10(3):196-202. doi: 10.2165/00002018-199410030-00002. Drug Saf. 1994. PMID: 8043222 Review.
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