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Degradation products of monoterpenes are the sensitizing agents in tea tree oil.
Hausen BM, Reichling J, Harkenthal M. Hausen BM, et al. Am J Contact Dermat. 1999 Jun;10(2):68-77. doi: 10.1016/s1046-199x(99)90002-7. Am J Contact Dermat. 1999. PMID: 10357714
Topical tea tree oil effective in canine localised pruritic dermatitis--a multi-centre randomised double-blind controlled clinical trial in the veterinary practice.
Reichling J, Fitzi J, Hellmann K, Wegener T, Bucher S, Saller R. Reichling J, et al. Dtsch Tierarztl Wochenschr. 2004 Oct;111(10):408-14. Dtsch Tierarztl Wochenschr. 2004. PMID: 15568640 Clinical Trial.
In vitro studies on release and human skin permeation of Australian tea tree oil (TTO) from topical formulations.
Reichling J, Landvatter U, Wagner H, Kostka KH, Schaefer UF. Reichling J, et al. Eur J Pharm Biopharm. 2006 Oct;64(2):222-8. doi: 10.1016/j.ejpb.2006.05.006. Epub 2006 May 23. Eur J Pharm Biopharm. 2006. PMID: 16846726
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