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Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice.
Gali CC, Fanaee-Danesh E, Zandl-Lang M, Albrecher NM, Tam-Amersdorfer C, Stracke A, Sachdev V, Reichmann F, Sun Y, Avdili A, Reiter M, Kratky D, Holzer P, Lass A, Kandimalla KK, Panzenboeck U. Gali CC, et al. Among authors: reichmann f. Mol Cell Neurosci. 2019 Sep;99:103390. doi: 10.1016/j.mcn.2019.103390. Epub 2019 Jul 2. Mol Cell Neurosci. 2019. PMID: 31276749 Free PMC article.
GAL3 receptor KO mice exhibit an anxiety-like phenotype.
Brunner SM, Farzi A, Locker F, Holub BS, Drexel M, Reichmann F, Lang AA, Mayr JA, Vilches JJ, Navarro X, Lang R, Sperk G, Holzer P, Kofler B. Brunner SM, et al. Among authors: reichmann f. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7138-43. doi: 10.1073/pnas.1318066111. Epub 2014 Apr 29. Proc Natl Acad Sci U S A. 2014. PMID: 24782539 Free PMC article.
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