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Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis.
Lee DH, Rötger C, Appeldoorn CC, Reijerkerk A, Gladdines W, Gaillard PJ, Linker RA. Lee DH, et al. Among authors: Reijerkerk A. J Neuroimmunol. 2014 Sep 15;274(1-2):96-101. doi: 10.1016/j.jneuroim.2014.06.025. Epub 2014 Jul 6. J Neuroimmunol. 2014. PMID: 25037177
Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation.
Gaillard PJ, Appeldoorn CC, Rip J, Dorland R, van der Pol SM, Kooij G, de Vries HE, Reijerkerk A. Gaillard PJ, et al. Among authors: Reijerkerk A. J Control Release. 2012 Dec 28;164(3):364-9. doi: 10.1016/j.jconrel.2012.06.022. Epub 2012 Jun 23. J Control Release. 2012. PMID: 22732475
Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood-brain barrier in rats.
Rip J, Chen L, Hartman R, van den Heuvel A, Reijerkerk A, van Kregten J, van der Boom B, Appeldoorn C, de Boer M, Maussang D, de Lange EC, Gaillard PJ. Rip J, et al. Among authors: Reijerkerk A. J Drug Target. 2014 Jun;22(5):460-7. doi: 10.3109/1061186X.2014.888070. Epub 2014 Feb 14. J Drug Target. 2014. PMID: 24524555 Free PMC article.
MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.
Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE, Hirst MC, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. Lopez-Ramirez MA, et al. Among authors: Reijerkerk A. FASEB J. 2014 Jun;28(6):2551-65. doi: 10.1096/fj.13-248880. Epub 2014 Mar 6. FASEB J. 2014. PMID: 24604078
Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier.
van Doorn R, Lopes Pinheiro MA, Kooij G, Lakeman K, van het Hof B, van der Pol SM, Geerts D, van Horssen J, van der Valk P, van der Kam E, Ronken E, Reijerkerk A, de Vries HE. van Doorn R, et al. Among authors: Reijerkerk A. J Neuroinflammation. 2012 Jun 20;9:133. doi: 10.1186/1742-2094-9-133. J Neuroinflammation. 2012. PMID: 22715976 Free PMC article.
Glutathione conjugation dose-dependently increases brain-specific liposomal drug delivery in vitro and in vivo.
Maussang D, Rip J, van Kregten J, van den Heuvel A, van der Pol S, van der Boom B, Reijerkerk A, Chen L, de Boer M, Gaillard P, de Vries H. Maussang D, et al. Among authors: Reijerkerk A. Drug Discov Today Technol. 2016 Jun;20:59-69. doi: 10.1016/j.ddtec.2016.09.003. Epub 2016 Oct 13. Drug Discov Today Technol. 2016. PMID: 27986226
Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions.
Nijland PG, Michailidou I, Witte ME, Mizee MR, van der Pol SM, van Het Hof B, Reijerkerk A, Pellerin L, van der Valk P, de Vries HE, van Horssen J. Nijland PG, et al. Among authors: Reijerkerk A. Glia. 2014 Jul;62(7):1125-41. doi: 10.1002/glia.22667. Epub 2014 Apr 1. Glia. 2014. PMID: 24692237
MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis.
Reijerkerk A, Lopez-Ramirez MA, van Het Hof B, Drexhage JA, Kamphuis WW, Kooij G, Vos JB, van der Pouw Kraan TC, van Zonneveld AJ, Horrevoets AJ, Prat A, Romero IA, de Vries HE. Reijerkerk A, et al. J Neurosci. 2013 Apr 17;33(16):6857-63. doi: 10.1523/JNEUROSCI.3965-12.2013. J Neurosci. 2013. PMID: 23595744 Free PMC article.
Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes.
van Doorn R, Nijland PG, Dekker N, Witte ME, Lopes-Pinheiro MA, van het Hof B, Kooij G, Reijerkerk A, Dijkstra C, van van der Valk P, van Horssen J, de Vries HE. van Doorn R, et al. Among authors: Reijerkerk A. Acta Neuropathol. 2012 Sep;124(3):397-410. doi: 10.1007/s00401-012-1014-4. Epub 2012 Jul 19. Acta Neuropathol. 2012. PMID: 22810490
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