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101 results
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Adapting to obesity with adipose tissue inflammation.
Reilly SM, Saltiel AR. Reilly SM, et al. Nat Rev Endocrinol. 2017 Nov;13(11):633-643. doi: 10.1038/nrendo.2017.90. Epub 2017 Aug 11. Nat Rev Endocrinol. 2017. PMID: 28799554 Review.
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.
Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. Reilly SM, et al. Nat Med. 2013 Mar;19(3):313-21. doi: 10.1038/nm.3082. Epub 2013 Feb 10. Nat Med. 2013. PMID: 23396211 Free PMC article.
Obesity: A complex role for adipose tissue macrophages.
Reilly SM, Saltiel AR. Reilly SM, et al. Nat Rev Endocrinol. 2014 Apr;10(4):193-4. doi: 10.1038/nrendo.2014.12. Epub 2014 Feb 4. Nat Rev Endocrinol. 2014. PMID: 24492182 No abstract available.
Countering inflammatory signals in obesity.
Reilly SM, Saltiel AR. Reilly SM, et al. Nat Immunol. 2014 May;15(5):410-1. doi: 10.1038/ni.2874. Nat Immunol. 2014. PMID: 24747704 No abstract available.
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. Fang S, et al. Nat Med. 2015 Feb;21(2):159-65. doi: 10.1038/nm.3760. Epub 2015 Jan 5. Nat Med. 2015. PMID: 25559344 Free PMC article.
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.
Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. Reilly SM, et al. Nat Commun. 2015 Jan 12;6:6047. doi: 10.1038/ncomms7047. Nat Commun. 2015. PMID: 25581158 Free PMC article. Clinical Trial.
A futile approach to fighting obesity?
Reilly SM, Saltiel AR. Reilly SM, et al. Cell. 2015 Oct 22;163(3):539-40. doi: 10.1016/j.cell.2015.10.006. Epub 2015 Oct 22. Cell. 2015. PMID: 26496598
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.
Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. Oral EA, et al. Cell Metab. 2017 Jul 5;26(1):157-170.e7. doi: 10.1016/j.cmet.2017.06.006. Cell Metab. 2017. PMID: 28683283 Free PMC article. Clinical Trial.
TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue.
Zhao P, Wong KI, Sun X, Reilly SM, Uhm M, Liao Z, Skorobogatko Y, Saltiel AR. Zhao P, et al. Cell. 2018 Feb 8;172(4):731-743.e12. doi: 10.1016/j.cell.2018.01.007. Cell. 2018. PMID: 29425491 Free PMC article.
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