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Innate recognition of intracellular pathogens: detection and activation of the first line of defense.
Rasmussen SB, Reinert LS, Paludan SR. Rasmussen SB, et al. Among authors: reinert ls. APMIS. 2009 May;117(5-6):323-37. doi: 10.1111/j.1600-0463.2009.02456.x. APMIS. 2009. PMID: 19400860 Review.
TLR2 and TLR9 synergistically control herpes simplex virus infection in the brain.
Sørensen LN, Reinert LS, Malmgaard L, Bartholdy C, Thomsen AR, Paludan SR. Sørensen LN, et al. Among authors: reinert ls. J Immunol. 2008 Dec 15;181(12):8604-12. doi: 10.4049/jimmunol.181.12.8604. J Immunol. 2008. PMID: 19050280
TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice.
Reinert LS, Harder L, Holm CK, Iversen MB, Horan KA, Dagnæs-Hansen F, Ulhøi BP, Holm TH, Mogensen TH, Owens T, Nyengaard JR, Thomsen AR, Paludan SR. Reinert LS, et al. J Clin Invest. 2012 Apr;122(4):1368-76. doi: 10.1172/JCI60893. Epub 2012 Mar 19. J Clin Invest. 2012. PMID: 22426207 Free PMC article.
Innate antiviral signalling in the central nervous system.
Carty M, Reinert L, Paludan SR, Bowie AG. Carty M, et al. Trends Immunol. 2014 Feb;35(2):79-87. doi: 10.1016/j.it.2013.10.012. Epub 2013 Dec 6. Trends Immunol. 2014. PMID: 24316012 Review.
Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections.
Kratholm SK, Iversen MB, Reinert L, Jensen SK, Hokland M, Andersen T, Rankin A, Young D, Frische S, Paludan SR, Holm CK. Kratholm SK, et al. PLoS One. 2013 Dec 16;8(12):e81790. doi: 10.1371/journal.pone.0081790. eCollection 2013. PLoS One. 2013. PMID: 24358128 Free PMC article.
TRAM is required for TLR2 endosomal signaling to type I IFN induction.
Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG. Stack J, et al. Among authors: reinert ls. J Immunol. 2014 Dec 15;193(12):6090-102. doi: 10.4049/jimmunol.1401605. Epub 2014 Nov 10. J Immunol. 2014. PMID: 25385819 Free PMC article.
NKT cell activation by local α-galactosylceramide administration decreases susceptibility to HSV-2 infection.
Iversen MB, Jensen SK, Hansen AL, Winther H, Issazadeh-Navikas S, Reinert LS, Holm CK. Iversen MB, et al. Among authors: reinert ls. Immunobiology. 2015 Jun;220(6):762-8. doi: 10.1016/j.imbio.2014.12.019. Epub 2015 Jan 21. Immunobiology. 2015. PMID: 25648689
An innate antiviral pathway acting before interferons at epithelial surfaces.
Iversen MB, Reinert LS, Thomsen MK, Bagdonaite I, Nandakumar R, Cheshenko N, Prabakaran T, Vakhrushev SY, Krzyzowska M, Kratholm SK, Ruiz-Perez F, Petersen SV, Goriely S, Bibby BM, Eriksson K, Ruland J, Thomsen AR, Herold BC, Wandall HH, Frische S, Holm CK, Paludan SR. Iversen MB, et al. Among authors: reinert ls. Nat Immunol. 2016 Feb;17(2):150-8. doi: 10.1038/ni.3319. Epub 2015 Nov 30. Nat Immunol. 2016. PMID: 26595890
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection.
Thomsen MK, Nandakumar R, Stadler D, Malo A, Valls RM, Wang F, Reinert LS, Dagnaes-Hansen F, Hollensen AK, Mikkelsen JG, Protzer U, Paludan SR. Thomsen MK, et al. Among authors: reinert ls. Hepatology. 2016 Sep;64(3):746-59. doi: 10.1002/hep.28685. Epub 2016 Jul 26. Hepatology. 2016. PMID: 27312012
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS.
Reinert LS, Lopušná K, Winther H, Sun C, Thomsen MK, Nandakumar R, Mogensen TH, Meyer M, Vægter C, Nyengaard JR, Fitzgerald KA, Paludan SR. Reinert LS, et al. Nat Commun. 2016 Nov 10;7:13348. doi: 10.1038/ncomms13348. Nat Commun. 2016. PMID: 27830700 Free PMC article.
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