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Investigating human disease using stem cell models.
Sterneckert JL, Reinhardt P, Schöler HR. Sterneckert JL, et al. Among authors: reinhardt p. Nat Rev Genet. 2014 Sep;15(9):625-39. doi: 10.1038/nrg3764. Epub 2014 Jul 29. Nat Rev Genet. 2014. PMID: 25069490 Review.
Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.
Marrone L, Bus C, Schöndorf D, Fitzgerald JC, Kübler M, Schmid B, Reinhardt P, Reinhardt L, Deleidi M, Levin T, Meixner A, Klink B, Glatza M, Gloeckner CJ, Gasser T, Sterneckert J. Marrone L, et al. Among authors: reinhardt p, reinhardt l. PLoS One. 2018 Mar 7;13(3):e0192497. doi: 10.1371/journal.pone.0192497. eCollection 2018. PLoS One. 2018. PMID: 29513666 Free PMC article.
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.
Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt JH, Holzmann K, Troost D, Ludolph AC, Boeckers TM, Liebau S, Petri S, Cordes N, Hyman AA, Wegner F, Grill SW, Weis J, Storch A, Hermann A. Naumann M, et al. Among authors: reinhardt p. Nat Commun. 2018 Jan 23;9(1):335. doi: 10.1038/s41467-017-02299-1. Nat Commun. 2018. PMID: 29362359 Free PMC article.
Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells.
Speidel A, Felk S, Reinhardt P, Sterneckert J, Gillardon F. Speidel A, et al. Among authors: reinhardt p. PLoS One. 2016 Nov 3;11(11):e0165949. doi: 10.1371/journal.pone.0165949. eCollection 2016. PLoS One. 2016. PMID: 27812199 Free PMC article.
Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging.
Japtok J, Lojewski X, Naumann M, Klingenstein M, Reinhardt P, Sterneckert J, Putz S, Demestre M, Boeckers TM, Ludolph AC, Liebau S, Storch A, Hermann A. Japtok J, et al. Among authors: reinhardt p. Neurobiol Dis. 2015 Oct;82:420-429. doi: 10.1016/j.nbd.2015.07.017. Epub 2015 Aug 4. Neurobiol Dis. 2015. PMID: 26253605
Molecular and functional analyses of motor neurons generated from human cord-blood-derived induced pluripotent stem cells.
Naujock M, Stanslowsky N, Reinhardt P, Sterneckert J, Haase A, Martin U, Kim KS, Dengler R, Wegner F, Petri S. Naujock M, et al. Among authors: reinhardt p. Stem Cells Dev. 2014 Dec 15;23(24):3011-20. doi: 10.1089/scd.2014.0180. Stem Cells Dev. 2014. PMID: 25007389
iPS cell derived neuronal cells for drug discovery.
Heilker R, Traub S, Reinhardt P, Schöler HR, Sterneckert J. Heilker R, et al. Among authors: reinhardt p. Trends Pharmacol Sci. 2014 Oct;35(10):510-9. doi: 10.1016/j.tips.2014.07.003. Epub 2014 Aug 3. Trends Pharmacol Sci. 2014. PMID: 25096281 Review.
Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway.
Lojewski X, Staropoli JF, Biswas-Legrand S, Simas AM, Haliw L, Selig MK, Coppel SH, Goss KA, Petcherski A, Chandrachud U, Sheridan SD, Lucente D, Sims KB, Gusella JF, Sondhi D, Crystal RG, Reinhardt P, Sterneckert J, Schöler H, Haggarty SJ, Storch A, Hermann A, Cotman SL. Lojewski X, et al. Among authors: reinhardt p. Hum Mol Genet. 2014 Apr 15;23(8):2005-22. doi: 10.1093/hmg/ddt596. Epub 2013 Nov 23. Hum Mol Genet. 2014. PMID: 24271013 Free PMC article.
The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis.
Nathan A, Reinhardt P, Kruspe D, Jörß T, Groth M, Nolte H, Habenicht A, Herrmann J, Holschbach V, Toth B, Krüger M, Wang ZQ, Platzer M, Englert C. Nathan A, et al. Among authors: reinhardt p. Hum Mol Genet. 2017 May 1;26(9):1694-1705. doi: 10.1093/hmg/ddx075. Hum Mol Genet. 2017. PMID: 28334862 Free PMC article.
Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.
Marrone L, Poser I, Casci I, Japtok J, Reinhardt P, Janosch A, Andree C, Lee HO, Moebius C, Koerner E, Reinhardt L, Cicardi ME, Hackmann K, Klink B, Poletti A, Alberti S, Bickle M, Hermann A, Pandey UB, Hyman AA, Sterneckert JL. Marrone L, et al. Among authors: reinhardt p, reinhardt l. Stem Cell Reports. 2018 Feb 13;10(2):375-389. doi: 10.1016/j.stemcr.2017.12.018. Epub 2018 Jan 18. Stem Cell Reports. 2018. PMID: 29358088 Free PMC article.
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