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The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties.
Freire ER, Dhalia R, Moura DM, da Costa Lima TD, Lima RP, Reis CR, Hughes K, Figueiredo RC, Standart N, Carrington M, de Melo Neto OP. Freire ER, et al. Among authors: reis cr. Mol Biochem Parasitol. 2011 Mar;176(1):25-36. doi: 10.1016/j.molbiopara.2010.11.011. Epub 2010 Nov 24. Mol Biochem Parasitol. 2011. PMID: 21111007 Free PMC article.
The two eIF4A helicases in Trypanosoma brucei are functionally distinct.
Dhalia R, Marinsek N, Reis CR, Katz R, Muniz JR, Standart N, Carrington M, de Melo Neto OP. Dhalia R, et al. Among authors: reis cr. Nucleic Acids Res. 2006 May 10;34(9):2495-507. doi: 10.1093/nar/gkl290. Print 2006. Nucleic Acids Res. 2006. PMID: 16687655 Free PMC article.
The eIF4E subunits of two distinct trypanosomatid eIF4F complexes are subjected to differential post-translational modifications associated to distinct growth phases in culture.
Pereira MM, Malvezzi AM, Nascimento LM, Lima TD, Alves VS, Palma ML, Freire ER, Moura DM, Reis CR, de Melo Neto OP. Pereira MM, et al. Among authors: reis cr. Mol Biochem Parasitol. 2013 Aug;190(2):82-6. doi: 10.1016/j.molbiopara.2013.06.008. Epub 2013 Jul 15. Mol Biochem Parasitol. 2013. PMID: 23867205 Free article.
The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation.
de Melo Neto OP, da Costa Lima TD, Xavier CC, Nascimento LM, Romão TP, Assis LA, Pereira MM, Reis CR, Papadopoulou B. de Melo Neto OP, et al. Among authors: reis cr. RNA Biol. 2015;12(11):1209-21. doi: 10.1080/15476286.2015.1086865. Epub 2015 Sep 4. RNA Biol. 2015. PMID: 26338184 Free PMC article.
61 results