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PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling.
Verbeek DS, Goedhart J, Bruinsma L, Sinke RJ, Reits EA. Verbeek DS, et al. J Cell Sci. 2008 Jul 15;121(Pt 14):2339-49. doi: 10.1242/jcs.027698. Epub 2008 Jun 24. J Cell Sci. 2008. PMID: 18577575
From fixed to FRAP: measuring protein mobility and activity in living cells.
Reits EA, Neefjes JJ. Reits EA, et al. Nat Cell Biol. 2001 Jun;3(6):E145-7. doi: 10.1038/35078615. Nat Cell Biol. 2001. PMID: 11389456 Review.
Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body.
van Lith M, van Ham M, Griekspoor A, Tjin E, Verwoerd D, Calafat J, Janssen H, Reits E, Pastoors L, Neefjes J. van Lith M, et al. J Immunol. 2001 Jul 15;167(2):884-92. doi: 10.4049/jimmunol.167.2.884. J Immunol. 2001. PMID: 11441095
Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C.
Villalba M, Bi K, Hu J, Altman Y, Bushway P, Reits E, Neefjes J, Baier G, Abraham RT, Altman A. Villalba M, et al. J Cell Biol. 2002 Apr 15;157(2):253-63. doi: 10.1083/jcb.200201097. Epub 2002 Apr 15. J Cell Biol. 2002. PMID: 11956228 Free PMC article.
Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity.
Raspe M, Gillis J, Krol H, Krom S, Bosch K, van Veen H, Reits E. Raspe M, et al. J Cell Sci. 2009 Sep 15;122(Pt 18):3262-71. doi: 10.1242/jcs.045567. Epub 2009 Aug 18. J Cell Sci. 2009. PMID: 19690053
Aminopeptidase-resistant peptides are targeted to lysosomes and subsequently degraded.
Gillis JM, Benckhuijsen W, van Veen H, Sanz AS, Drijfhout JW, Reits EA. Gillis JM, et al. Traffic. 2011 Dec;12(12):1897-910. doi: 10.1111/j.1600-0854.2011.01270.x. Epub 2011 Sep 19. Traffic. 2011. PMID: 21883763
Alternative macroautophagic pathways.
Juenemann K, Reits EA. Juenemann K, et al. Int J Cell Biol. 2012;2012:189794. doi: 10.1155/2012/189794. Epub 2012 Mar 27. Int J Cell Biol. 2012. PMID: 22536246 Free PMC article.
The Ubiquitin-Proteasome System in Huntington's Disease: Are Proteasomes Impaired, Initiators of Disease, or Coming to the Rescue?
Schipper-Krom S, Juenemann K, Reits EA. Schipper-Krom S, et al. Biochem Res Int. 2012;2012:837015. doi: 10.1155/2012/837015. Epub 2012 Sep 24. Biochem Res Int. 2012. PMID: 23050151 Free PMC article.
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