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SCA14 mutation V138E leads to partly unfolded PKCγ associated with an exposed C-terminus, altered kinetics, phosphorylation and enhanced insolubilization.
Jezierska J, Goedhart J, Kampinga HH, Reits EA, Verbeek DS. Jezierska J, et al. Among authors: reits ea. J Neurochem. 2014 Mar;128(5):741-51. doi: 10.1111/jnc.12491. Epub 2013 Nov 13. J Neurochem. 2014. PMID: 24134140
Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes.
Schipper-Krom S, Sanz AS, van Bodegraven EJ, Speijer D, Florea BI, Ovaa H, Reits EA. Schipper-Krom S, et al. Among authors: reits ea. Front Mol Biosci. 2019 Aug 20;6:56. doi: 10.3389/fmolb.2019.00056. eCollection 2019. Front Mol Biosci. 2019. PMID: 31482094 Free PMC article.
PKC gamma mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling.
Verbeek DS, Goedhart J, Bruinsma L, Sinke RJ, Reits EA. Verbeek DS, et al. Among authors: reits ea. J Cell Sci. 2008 Jul 15;121(Pt 14):2339-49. doi: 10.1242/jcs.027698. Epub 2008 Jun 24. J Cell Sci. 2008. PMID: 18577575
Altered secondary structure of Dynorphin A associates with loss of opioid signalling and NMDA-mediated excitotoxicity in SCA23.
Smeets CJ, Zmorzyńska J, Melo MN, Stargardt A, Dooley C, Bakalkin G, McLaughlin J, Sinke RJ, Marrink SJ, Reits E, Verbeek DS. Smeets CJ, et al. Hum Mol Genet. 2016 Jul 1;25(13):2728-2737. doi: 10.1093/hmg/ddw130. Epub 2016 Jun 3. Hum Mol Genet. 2016. PMID: 27260403
Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation.
Krol HA, Krawczyk PM, Bosch KS, Aten JA, Hol EM, Reits EA. Krol HA, et al. Among authors: reits ea. PLoS One. 2008 Jan 30;3(1):e1503. doi: 10.1371/journal.pone.0001503. PLoS One. 2008. PMID: 18231590 Free PMC article.
Opposing motor activities of dynein and kinesin determine retention and transport of MHC class II-containing compartments.
Wubbolts R, Fernandez-Borja M, Jordens I, Reits E, Dusseljee S, Echeverri C, Vallee RB, Neefjes J. Wubbolts R, et al. J Cell Sci. 1999 Mar;112 ( Pt 6):785-95. J Cell Sci. 1999. PMID: 10036229
Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body.
van Lith M, van Ham M, Griekspoor A, Tjin E, Verwoerd D, Calafat J, Janssen H, Reits E, Pastoors L, Neefjes J. van Lith M, et al. J Immunol. 2001 Jul 15;167(2):884-92. doi: 10.4049/jimmunol.167.2.884. J Immunol. 2001. PMID: 11441095
Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.
Menzies FM, Hourez R, Imarisio S, Raspe M, Sadiq O, Chandraratna D, O'Kane C, Rock KL, Reits E, Goldberg AL, Rubinsztein DC. Menzies FM, et al. Hum Mol Genet. 2010 Dec 1;19(23):4573-86. doi: 10.1093/hmg/ddq385. Epub 2010 Sep 9. Hum Mol Genet. 2010. PMID: 20829225 Free PMC article.
Alternative macroautophagic pathways.
Juenemann K, Reits EA. Juenemann K, et al. Among authors: reits ea. Int J Cell Biol. 2012;2012:189794. doi: 10.1155/2012/189794. Epub 2012 Mar 27. Int J Cell Biol. 2012. PMID: 22536246 Free PMC article.
Kinetic studies of cytoplasmic antigen processing and production of MHC class I ligands.
Stargardt A, Reits E. Stargardt A, et al. Methods Mol Biol. 2013;960:41-51. doi: 10.1007/978-1-62703-218-6_4. Methods Mol Biol. 2013. PMID: 23329477
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