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The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.
Bhattacharyya RP, Reményi A, Good MC, Bashor CJ, Falick AM, Lim WA. Bhattacharyya RP, et al. Among authors: remenyi a. Science. 2006 Feb 10;311(5762):822-6. doi: 10.1126/science.1120941. Epub 2006 Jan 19. Science. 2006. PMID: 16424299
We found that the Ste5 scaffold has a more active role in the yeast mating pathway: A fragment of Ste5 allosterically activated autophosphorylation of the mitogen-activated protein kinase Fus3. ...Unexpectedly, at a systems level, autoactivated Fus3 appears t …
We found that the Ste5 scaffold has a more active role in the yeast mating pathway: A fragment of Ste5 allosterically activate …
Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.
Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim WA, Kortemme T. Kapp GT, et al. Among authors: remenyi a. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5277-82. doi: 10.1073/pnas.1114487109. Epub 2012 Mar 7. Proc Natl Acad Sci U S A. 2012. PMID: 22403064 Free PMC article.
Here we demonstrate a strategy for improving and simplifying protein network engineering: using computational design to create orthogonal (non-crossreacting) protein-protein interfaces. We validated the design of the interface between a key signaling protein, the GT …
Here we demonstrate a strategy for improving and simplifying protein network engineering: using computational design to create orthog …
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs.
Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, Sheu YJ, Sassi HE, Sopko R, Chan CS, De Virgilio C, Hollingsworth NM, Lim WA, Stern DF, Stillman B, Andrews BJ, Gerstein MB, Snyder M, Turk BE. Mok J, et al. Among authors: remenyi a. Sci Signal. 2010 Feb 16;3(109):ra12. doi: 10.1126/scisignal.2000482. Sci Signal. 2010. PMID: 20159853 Free PMC article.
We used a rapid peptide screening approach to determine consensus phosphorylation site motifs targeted by 61 of the 122 kinases in Saccharomyces cerevisiae. ...We experimentally verified several candidate substrates of the Prk1 family of kinases in vitro and in vivo and id …
We used a rapid peptide screening approach to determine consensus phosphorylation site motifs targeted by 61 of the 122 kinases in Sa …
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation.
Good M, Tang G, Singleton J, Reményi A, Lim WA. Good M, et al. Among authors: remenyi a. Cell. 2009 Mar 20;136(6):1085-97. doi: 10.1016/j.cell.2009.01.049. Cell. 2009. PMID: 19303851 Free PMC article.
We identify and structurally characterize a domain in Ste5 that catalytically unlocks Fus3 for phosphorylation by Ste7. This domain selectively increases the k(cat) of Ste7-->Fus3 phosphorylation but has no effect on Ste7-->Kss1 phosphorylation. ...
We identify and structurally characterize a domain in Ste5 that catalytically unlocks Fus3 for phosphorylation by Ste7. This domain s …
Docking interactions in protein kinase and phosphatase networks.
Reményi A, Good MC, Lim WA. Reményi A, et al. Curr Opin Struct Biol. 2006 Dec;16(6):676-85. doi: 10.1016/j.sbi.2006.10.008. Epub 2006 Oct 31. Curr Opin Struct Biol. 2006. PMID: 17079133 Review.
Although the role of modular protein-protein interaction domains in kinase and phosphatase signaling has been well characterized, it is becoming clear that many kinases and phosphatases utilize docking interactions - recognition of a short peptide motif in target partners …
Although the role of modular protein-protein interaction domains in kinase and phosphatase signaling has been well characterized, it is beco …
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits.
Bhattacharyya RP, Reményi A, Yeh BJ, Lim WA. Bhattacharyya RP, et al. Among authors: remenyi a. Annu Rev Biochem. 2006;75:655-80. doi: 10.1146/annurev.biochem.75.103004.142710. Annu Rev Biochem. 2006. PMID: 16756506 Review.
Many of the mechanisms that connect signaling proteins into networks are highly modular: The core catalytic activity of a signaling protein is physically and functionally separable from molecular domains or motifs that determine its linkage to both inputs and outputs. ...
Many of the mechanisms that connect signaling proteins into networks are highly modular: The core catalytic activity of a signaling p …
The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Reményi A, Good MC, Bhattacharyya RP, Lim WA. Reményi A, et al. Mol Cell. 2005 Dec 22;20(6):951-62. doi: 10.1016/j.molcel.2005.10.030. Mol Cell. 2005. PMID: 16364919
Cells use a network of mitogen-activated protein kinases (MAPKs) to coordinate responses to diverse extracellular signals. Here, we examine the role of docking interactions in determining connectivity of the yeast MAPKs Fus3 and Kss1. ...The cell cycle arrest mediator Far1 …
Cells use a network of mitogen-activated protein kinases (MAPKs) to coordinate responses to diverse extracellular signals. Here, we e …
JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships.
Zeke A, Misheva M, Reményi A, Bogoyevitch MA. Zeke A, et al. Among authors: remenyi a. Microbiol Mol Biol Rev. 2016 Jul 27;80(3):793-835. doi: 10.1128/MMBR.00043-14. Print 2016 Sep. Microbiol Mol Biol Rev. 2016. PMID: 27466283 Free PMC article. Review.
Here we review the current knowledge of JNK structure and isoforms as well as the partnerships of JNKs with a range of intracellular proteins. ...We analyzed almost 100 of these target proteins in detail within a framework of their classification based on their regu …
Here we review the current knowledge of JNK structure and isoforms as well as the partnerships of JNKs with a range of intracellular …
The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism.
Gógl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetényi C, Reményi A, Weiss EL. Gógl G, et al. Among authors: remenyi a. PLoS Biol. 2015 May 12;13(5):e1002146. doi: 10.1371/journal.pbio.1002146. eCollection 2015 May. PLoS Biol. 2015. PMID: 25966461 Free PMC article.
It shows a novel coactivator-organized activation region that may be unique to NDR/LATS kinases, in which a key regulatory motif apparently shifts from an inactive binding mode to an active one upon phosphorylation. We also provide a structural basis for a
It shows a novel coactivator-organized activation region that may be unique to NDR/LATS kinases, in which a key regulatory mot …
Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development.
Mészáros B, Zeke A, Reményi A, Simon I, Dosztányi Z. Mészáros B, et al. Among authors: remenyi a. Biol Direct. 2016 May 5;11:23. doi: 10.1186/s13062-016-0125-6. Biol Direct. 2016. PMID: 27150584 Free PMC article.
RESULTS: In this work we present a novel method called iSiMPRe that identifies regions that are significantly enriched in somatic mutations and short in-frame insertions or deletions (indels). ...These results indicate that the accumulation of local somatic mutations can b …
RESULTS: In this work we present a novel method called iSiMPRe that identifies regions that are significantly enriched in somatic mut …
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