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Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.
Mathupala SP, Rempel A, Pedersen PL. Mathupala SP, et al. Among authors: rempel a. J Biol Chem. 2001 Nov 16;276(46):43407-12. doi: 10.1074/jbc.M108181200. Epub 2001 Sep 13. J Biol Chem. 2001. PMID: 11557773
Reporter gene analyses with a series of nested deletion mutants of the hepatoma type II hexokinase promoter show that a significant fraction of the total activation observed under hypoxic conditions localizes to the distal region where the overlapping HIF-1/E-box se …
Reporter gene analyses with a series of nested deletion mutants of the hepatoma type II hexokinase promoter show that a signif …
Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention.
Pedersen PL, Mathupala S, Rempel A, Geschwind JF, Ko YH. Pedersen PL, et al. Among authors: rempel a. Biochim Biophys Acta. 2002 Sep 10;1555(1-3):14-20. doi: 10.1016/s0005-2728(02)00248-7. Biochim Biophys Acta. 2002. PMID: 12206885
Significantly, one of the earliest discovered hallmarks of cancer had its roots in Bioenergetics as many tumors were found in the 1920s to exhibit a high glycolytic phenotype. ...Thus, we now have a much better molecular understanding of the high glycolytic phenotyp …
Significantly, one of the earliest discovered hallmarks of cancer had its roots in Bioenergetics as many tumors were found in the 1920s to e …
Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.
Mathupala SP, Rempel A, Pedersen PL. Mathupala SP, et al. Among authors: rempel a. J Bioenerg Biomembr. 1997 Aug;29(4):339-43. doi: 10.1023/a:1022494613613. J Bioenerg Biomembr. 1997. PMID: 9387094 Review.
This common biochemical signature of many cancers, particularly those that are poorly differentiated and proliferate rapidly, has remained until recently a "metabolic enigma." ...The enzyme's gene promoter, in turn, shows a wide promiscuity toward the signal transdu …
This common biochemical signature of many cancers, particularly those that are poorly differentiated and proliferate rapidly, has remained u …
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
Rempel A, Mathupala SP, Griffin CA, Hawkins AL, Pedersen PL. Rempel A, et al. Cancer Res. 1996 Jun 1;56(11):2468-71. Cancer Res. 1996. PMID: 8653677
Hexokinase type II is highly overexpressed in many cancer cells, where it plays a pivotal role in the high glycolytic phenotype. ...This is the first report describing the amplification of a hexokinase gene in a tumor cell line expressing the high glycolytic …
Hexokinase type II is highly overexpressed in many cancer cells, where it plays a pivotal role in the high glycolytic phenotype. ...T …
Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP.
Rempel A, Mathupala SP, Perdersen PL. Rempel A, et al. FEBS Lett. 1996 May 6;385(3):233-7. doi: 10.1016/0014-5793(96)00399-7. FEBS Lett. 1996. PMID: 8647258
The increased glucose consumption of many tumor cells depends to a large extent on the overexpression of hexokinase Type II. In a previous study we isolated and sequenced the hepatoma Type II hexokinase promoter and showed that it is activated by glucose in the high …
The increased glucose consumption of many tumor cells depends to a large extent on the overexpression of hexokinase Type II. In a
Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase.
Mathupala SP, Rempel A, Pedersen PL. Mathupala SP, et al. Among authors: rempel a. J Biol Chem. 1995 Jul 14;270(28):16918-25. doi: 10.1074/jbc.270.28.16918. J Biol Chem. 1995. PMID: 7622509
Here we report the isolation and sequence of a 4.3-kilobase pair proximal promoter region of the Type II hexokinase gene from a rapidly growing, highly glycolytic hepatoma cell line (AS-30D). Analysis of the sequence enabled the identification of putative promoter e …
Here we report the isolation and sequence of a 4.3-kilobase pair proximal promoter region of the Type II hexokinase gene from a
Differences in expression and intracellular distribution of hexokinase isoenzymes in rat liver cells of different transformation stages.
Rempel A, Bannasch P, Mayer D. Rempel A, et al. Biochim Biophys Acta. 1994 Nov 22;1219(3):660-8. doi: 10.1016/0167-4781(94)90225-9. Biochim Biophys Acta. 1994. PMID: 7948023
IIa-activity showed a good correlation with the intracellular glucose 6-phosphate concentration of the cells. The data indicate that neoplastic cell transformation is accompanied by progressive alterations in the proportion and subcellular distribution of hexokinase isoenz …
IIa-activity showed a good correlation with the intracellular glucose 6-phosphate concentration of the cells. The data indicate that …
Hexokinase expression in liver preneoplasia and neoplasia.
Mayer D, Klimek F, Rempel A, Bannasch P. Mayer D, et al. Among authors: rempel a. Biochem Soc Trans. 1997 Feb;25(1):122-7. doi: 10.1042/bst0250122. Biochem Soc Trans. 1997. PMID: 9056856 Review. No abstract available.
Microheterogeneity of cytosolic and membrane-bound hexokinase II in Morris hepatoma 3924A.
Rempel A, Bannasch P, Mayer D. Rempel A, et al. Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):269-74. doi: 10.1042/bj3030269. Biochem J. 1994. PMID: 7945251 Free PMC article.
Binding of the isolated forms of the enzyme to rat liver mitochondria resulted in a 2-10-fold activation of both subtypes. Biochemical characterization showed that both subtypes are closely related to the isoenzyme commonly referred to as hexokinase II, and that the microh …
Binding of the isolated forms of the enzyme to rat liver mitochondria resulted in a 2-10-fold activation of both subtypes. Biochemica …
Elevated content of p53 protein in the absence of p53 gene mutations as a possible prognostic marker for human renal cell tumors.
Chemeris G, Loktinov A, Rempel A, Schwarz M, Bannasch P. Chemeris G, et al. Among authors: rempel a. Virchows Arch. 1995;426(6):563-9. doi: 10.1007/BF00192110. Virchows Arch. 1995. PMID: 7655736
Accumulation of the wild-type p53 protein may be a useful prognostic marker indicating neoplastic progression malignancy....
Accumulation of the wild-type p53 protein may be a useful prognostic marker indicating neoplastic progression malignancy....
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