Ren X - Search Results

1

Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors.

Gao M, Duan L, Luo J, Zhang L, Lu X, Zhang Y, Zhang Z, Tu Z, Xu Y, Ren X, Ding K. Gao M, et al. Among authors: ren x. J Med Chem. 2013 Apr 25;56(8):3281-95. doi: 10.1021/jm301824k. Epub 2013 Apr 10. J Med Chem. 2013. PMID: 23521020

2

Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents.

Zhou J, Duan L, Chen H, Ren X, Zhang Z, Zhou F, Liu J, Pei D, Ding K. Zhou J, et al. Among authors: ren x. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5091-4. doi: 10.1016/j.bmcl.2009.07.044. Epub 2009 Jul 10. Bioorg Med Chem Lett. 2009. PMID: 19632833

3

A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton.

Zhang J, Zhou J, Ren X, Diao Y, Li H, Jiang H, Ding K, Pei D. Zhang J, et al. Among authors: ren x. Invest New Drugs. 2012 Apr;30(2):490-507. doi: 10.1007/s10637-010-9577-1. Epub 2010 Nov 16. Invest New Drugs. 2012. PMID: 21080210

4

Hybrid compounds as new Bcr/Abl inhibitors.

Wang D, Zhang Z, Lu X, Feng Y, Luo K, Gan J, Yingxue L, Wan J, Li X, Zhang F, Tu Z, Cai Q, Ren X, Ding K. Wang D, et al. Among authors: ren x. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1965-8. doi: 10.1016/j.bmcl.2011.02.029. Epub 2011 Feb 13. Bioorg Med Chem Lett. 2011. PMID: 21376587

5

Identification of pyrido[1,2-α]pyrimidine-4-ones as new molecules improving the transcriptional functions of estrogen-related receptor α.

Peng L, Gao X, Duan L, Ren X, Wu D, Ding K. Peng L, et al. Among authors: ren x. J Med Chem. 2011 Nov 10;54(21):7729-33. doi: 10.1021/jm200976s. Epub 2011 Oct 12. J Med Chem. 2011. PMID: 21958216

6

New thiazole carboxamides as potent inhibitors of Akt kinases.

Chang S, Zhang Z, Zhuang X, Luo J, Cao X, Li H, Tu Z, Lu X, Ren X, Ding K. Chang S, et al. Among authors: ren x. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1208-12. doi: 10.1016/j.bmcl.2011.11.080. Epub 2011 Nov 30. Bioorg Med Chem Lett. 2012. PMID: 22172705

7

Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant.

Chang S, Zhang L, Xu S, Luo J, Lu X, Zhang Z, Xu T, Liu Y, Tu Z, Xu Y, Ren X, Geng M, Ding J, Pei D, Ding K. Chang S, et al. Among authors: ren x. J Med Chem. 2012 Mar 22;55(6):2711-23. doi: 10.1021/jm201591k. Epub 2012 Mar 1. J Med Chem. 2012. PMID: 22339342

8

Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.

Li Y, Shen M, Zhang Z, Luo J, Pan X, Lu X, Long H, Wen D, Zhang F, Leng F, Li Y, Tu Z, Ren X, Ding K. Li Y, et al. Among authors: ren x. J Med Chem. 2012 Nov 26;55(22):10033-46. doi: 10.1021/jm301188x. Epub 2012 Nov 1. J Med Chem. 2012. PMID: 23088644

9

Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.

Ren X, Pan X, Zhang Z, Wang D, Lu X, Li Y, Wen D, Long H, Luo J, Feng Y, Zhuang X, Zhang F, Liu J, Leng F, Lang X, Bai Y, She M, Tu Z, Pan J, Ding K. Ren X, et al. J Med Chem. 2013 Feb 14;56(3):879-94. doi: 10.1021/jm301581y. Epub 2013 Jan 28. J Med Chem. 2013. PMID: 23301703

10

1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptor α.

Xu S, Zhuang X, Pan X, Zhang Z, Duan L, Liu Y, Zhang L, Ren X, Ding K. Xu S, et al. Among authors: ren x. J Med Chem. 2013 Jun 13;56(11):4631-40. doi: 10.1021/jm4003928. Epub 2013 May 24. J Med Chem. 2013. PMID: 23656512

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