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94 results
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Drug discovery and development for neglected parasitic diseases.
Renslo AR, McKerrow JH. Renslo AR, et al. Nat Chem Biol. 2006 Dec;2(12):701-10. doi: 10.1038/nchembio837. Nat Chem Biol. 2006. PMID: 17108988 Review.
Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine.
Bashore C, Jaishankar P, Skelton NJ, Fuhrmann J, Hearn BR, Liu PS, Renslo AR, Dueber EC. Bashore C, et al. Among authors: renslo ar. ACS Chem Biol. 2020 Jun 19;15(6):1392-1400. doi: 10.1021/acschembio.0c00031. Epub 2020 Apr 17. ACS Chem Biol. 2020. PMID: 32302100
Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.
Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey CR. Abdulla MH, et al. Among authors: renslo ar. PLoS Negl Trop Dis. 2009 Jul 14;3(7):e478. doi: 10.1371/journal.pntd.0000478. PLoS Negl Trop Dis. 2009. PMID: 19597541 Free PMC article.
Divergent modes of enzyme inhibition in a homologous structure-activity series.
Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. Ferreira RS, et al. Among authors: renslo ar. J Med Chem. 2009 Aug 27;52(16):5005-8. doi: 10.1021/jm9009229. J Med Chem. 2009. PMID: 19637873 Free PMC article.
Discovery of 2-aminothiazoles as potent antiprion compounds.
Ghaemmaghami S, May BC, Renslo AR, Prusiner SB. Ghaemmaghami S, et al. Among authors: renslo ar. J Virol. 2010 Apr;84(7):3408-12. doi: 10.1128/JVI.02145-09. Epub 2009 Dec 23. J Virol. 2010. PMID: 20032192 Free PMC article.
2-Aminothiazoles as therapeutic leads for prion diseases.
Gallardo-Godoy A, Gever J, Fife KL, Silber BM, Prusiner SB, Renslo AR. Gallardo-Godoy A, et al. Among authors: renslo ar. J Med Chem. 2011 Feb 24;54(4):1010-21. doi: 10.1021/jm101250y. Epub 2011 Jan 19. J Med Chem. 2011. PMID: 21247166 Free PMC article.
Mining a cathepsin inhibitor library for new antiparasitic drug leads.
Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Ang KK, et al. Among authors: renslo ar. PLoS Negl Trop Dis. 2011 May 3;5(5):e1023. doi: 10.1371/journal.pntd.0001023. PLoS Negl Trop Dis. 2011. PMID: 21572521 Free PMC article.
Drug discovery for neglected tropical diseases at the Sandler Center.
Robertson SA, Renslo AR. Robertson SA, et al. Among authors: renslo ar. Future Med Chem. 2011 Aug;3(10):1279-88. doi: 10.4155/fmc.11.85. Future Med Chem. 2011. PMID: 21859302 Free PMC article.
A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.
Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL Jr. Bagriantsev SN, et al. Among authors: renslo ar. ACS Chem Biol. 2013 Aug 16;8(8):1841-51. doi: 10.1021/cb400289x. Epub 2013 Jun 17. ACS Chem Biol. 2013. PMID: 23738709 Free PMC article.
Drug resistance confounding prion therapeutics.
Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K. Berry DB, et al. Among authors: renslo ar. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):E4160-9. doi: 10.1073/pnas.1317164110. Epub 2013 Oct 15. Proc Natl Acad Sci U S A. 2013. PMID: 24128760 Free PMC article.
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