Repke DB - Search Results

1

Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors.

Clark RD, Repke DB, Berger J, Nelson JT, Kilpatrick AT, Brown CM, MacKinnon AC, Clague RU, Spedding M. Clark RD, et al. Among authors: repke db. J Med Chem. 1991 Feb;34(2):705-17. doi: 10.1021/jm00106a036. J Med Chem. 1991. PMID: 1671705

2

(8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- 3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridi ne, a potent and highly selective alpha 2-adrenoceptor antagonist.

Clark RD, Repke DB, Kilpatrick AT, Brown CM, MacKinnon AC, Clague RU, Spedding M. Clark RD, et al. Among authors: repke db. J Med Chem. 1989 Sep;32(9):2034-6. doi: 10.1021/jm00129a002. J Med Chem. 1989. PMID: 2570150 No abstract available.

3

2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists.

Clark RD, Miller AB, Berger J, Repke DB, Weinhardt KK, Kowalczyk BA, Eglen RM, Bonhaus DW, Lee CH, Michel AD, et al. Clark RD, et al. Among authors: repke db. J Med Chem. 1993 Sep 3;36(18):2645-57. doi: 10.1021/jm00070a008. J Med Chem. 1993. PMID: 8410977

4

Structure-activity relationships for 2-substituted imidazoles as alpha 2-adrenoceptor antagonists.

Caroon JM, Clark RD, Kluge AF, Olah R, Repke DB, Unger SH, Michel AD, Whiting RL. Caroon JM, et al. Among authors: repke db. J Med Chem. 1982 Jun;25(6):666-70. doi: 10.1021/jm00348a012. J Med Chem. 1982. PMID: 6124635

5

Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones.

Clark RD, Caroon JM, Repke DB, Strosberg AM, Bitter SM, Okada MD, Michel AD, Whiting RL. Clark RD, et al. Among authors: repke db. J Med Chem. 1983 Jun;26(6):855-61. doi: 10.1021/jm00360a013. J Med Chem. 1983. PMID: 6133954

6

N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.

Elworthy TR, Ford AP, Bantle GW, Morgans DJ Jr, Ozer RS, Palmer WS, Repke DB, Romero M, Sandoval L, Sjogren EB, Talamás FX, Vazquez A, Wu H, Arredondo NF, Blue DR Jr, DeSousa A, Gross LM, Kava MS, Lesnick JD, Vimont RL, Williams TJ, Zhu QM, Pfister JR, Clarke DE. Elworthy TR, et al. Among authors: repke db. J Med Chem. 1997 Aug 15;40(17):2674-87. doi: 10.1021/jm970166j. J Med Chem. 1997. PMID: 9276013

7

Antihypertensive aminotetralins related to labetalol and medroxalol.

Clark RD, Caroon JM, Repke DB, Strosberg AM, Whiting RL, Brown CM. Clark RD, et al. Among authors: repke db. J Pharm Sci. 1986 Jan;75(1):80-2. doi: 10.1002/jps.2600750119. J Pharm Sci. 1986. PMID: 3007731

8

Antihypertensive 1-acyl-4-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethylamino]pip eridines.

Caroon JM, Clark RD, Repke DB, Kluge AF, Strosberg AM, Whiting RL, Okada MD, Hedley LR, Van Antwerp D, Brown CM. Caroon JM, et al. Among authors: repke db. J Pharm Sci. 1987 Jan;76(1):32-4. doi: 10.1002/jps.2600760110. J Pharm Sci. 1987. PMID: 3035169

9

Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones.

Clark RD, Caroon JM, Kluge AF, Repke DB, Roszkowski AP, Strosberg AM, Baker S, Bitter SM, Okada MD. Clark RD, et al. Among authors: repke db. J Med Chem. 1983 May;26(5):657-61. doi: 10.1021/jm00359a007. J Med Chem. 1983. PMID: 6842505

10

Highly potent, non-basic 5-HT6 ligands. Site mutagenesis evidence for a second binding mode at 5-HT6 for antagonism.

Harris RN 3rd, Stabler RS, Repke DB, Kress JM, Walker KA, Martin RS, Brothers JM, Ilnicka M, Lee SW, Mirzadegan T. Harris RN 3rd, et al. Among authors: repke db. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3436-40. doi: 10.1016/j.bmcl.2010.03.110. Epub 2010 Apr 1. Bioorg Med Chem Lett. 2010. PMID: 20434910

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