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Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.
Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA, Kuiper RV, Nagarajah B, van Oostrom CT, Brandt RM, Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis Á, Pothof J, Vijg J, van Steeg H, Hoeijmakers JH. Vermeij WP, et al. Nature. 2016 Sep 15;537(7620):427-431. doi: 10.1038/nature19329. Epub 2016 Aug 24. Nature. 2016. PMID: 27556946 Free PMC article.
Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1( /-)) show numerous accelerated ageing features that limit their lifespan to 4-6 months. ...Other DNA-repair-deficient, progeroid Xpg(-/-) (also known as Erc …
Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1( /-)) show numerous accelerated ageing …
Delayed and accelerated aging share common longevity assurance mechanisms.
Schumacher B, van der Pluijm I, Moorhouse MJ, Kosteas T, Robinson AR, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JH, van der Horst GT, Garinis GA. Schumacher B, et al. PLoS Genet. 2008 Aug 15;4(8):e1000161. doi: 10.1371/journal.pgen.1000161. PLoS Genet. 2008. PMID: 18704162 Free PMC article.
Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. ...However, on a genome-wide scale, tr …
Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse mod …