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Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes.
Aschrafi A, Sadtler S, Niculescu C, Rettinger J, Schmalzing G. Aschrafi A, et al. J Mol Biol. 2004 Sep 3;342(1):333-43. doi: 10.1016/j.jmb.2004.06.092. J Mol Biol. 2004. PMID: 15313628
Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist.
Rettinger J, Braun K, Hochmann H, Kassack MU, Ullmann H, Nickel P, Schmalzing G, Lambrecht G. Rettinger J, et al. Neuropharmacology. 2005 Mar;48(3):461-8. doi: 10.1016/j.neuropharm.2004.11.003. Neuropharmacology. 2005. PMID: 15721178
Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.
Lörinczi É, Bhargava Y, Marino SF, Taly A, Kaczmarek-Hájek K, Barrantes-Freer A, Dutertre S, Grutter T, Rettinger J, Nicke A. Lörinczi É, et al. Among authors: rettinger j. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11396-401. doi: 10.1073/pnas.1118759109. Epub 2012 Jun 27. Proc Natl Acad Sci U S A. 2012. PMID: 22745172 Free PMC article.
Inter-subunit disulfide cross-linking in homomeric and heteromeric P2X receptors.
Marquez-Klaka B, Rettinger J, Nicke A. Marquez-Klaka B, et al. Among authors: rettinger j. Eur Biophys J. 2009 Mar;38(3):329-38. doi: 10.1007/s00249-008-0325-9. Epub 2008 Apr 22. Eur Biophys J. 2009. PMID: 18427801
Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor.
Marquez-Klaka B, Rettinger J, Bhargava Y, Eisele T, Nicke A. Marquez-Klaka B, et al. Among authors: rettinger j. J Neurosci. 2007 Feb 7;27(6):1456-66. doi: 10.1523/JNEUROSCI.3105-06.2007. J Neurosci. 2007. PMID: 17287520 Free PMC article.
The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups.
Hausmann R, Rettinger J, Gerevich Z, Meis S, Kassack MU, Illes P, Lambrecht G, Schmalzing G. Hausmann R, et al. Among authors: rettinger j. Mol Pharmacol. 2006 Jun;69(6):2058-67. doi: 10.1124/mol.106.022665. Epub 2006 Mar 21. Mol Pharmacol. 2006. PMID: 16551782
Desensitization masks nanomolar potency of ATP for the P2X1 receptor.
Rettinger J, Schmalzing G. Rettinger J, et al. J Biol Chem. 2004 Feb 20;279(8):6426-33. doi: 10.1074/jbc.M306987200. Epub 2003 Nov 18. J Biol Chem. 2004. PMID: 14625300
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