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Ethical Considerations Related to Return of Results from Genomic Medicine Projects: The eMERGE Network (Phase III) Experience.
Fossey R, Kochan D, Winkler E, Pacyna JE, Olson J, Thibodeau S, Connolly JJ, Harr M, Behr MA, Prows CA, Cobb B, Myers MF, Leslie ND, Namjou-Khales B, Milo Rasouly H, Wynn J, Fedotov A, Chung WK, Gharavi A, Williams JL, Pais L, Holm I, Aufox S, Smith ME, Scrol A, Leppig K, Jarvik GP, Wiesner GL, Li R, Stroud M, Smoller JW, Sharp RR, Kullo IJ. Fossey R, et al. J Pers Med. 2018 Jan 3;8(1):2. doi: 10.3390/jpm8010002. J Pers Med. 2018. PMID: 29301385 Free PMC article.
We examined the Institutional Review Board (IRB) process at 9 academic institutions in the electronic Medical Records and Genomics (eMERGE) Network, for proposed electronic health record-based genomic medicine studies, to identify common questions and …
We examined the Institutional Review Board (IRB) process at 9 academic institutions in the electronic Medical Records and Genomics (eMERG
Return of results in the genomic medicine projects of the eMERGE network.
Kullo IJ, Haddad R, Prows CA, Holm I, Sanderson SC, Garrison NA, Sharp RR, Smith ME, Kuivaniemi H, Bottinger EP, Connolly JJ, Keating BJ, McCarty CA, Williams MS, Jarvik GP. Kullo IJ, et al. Front Genet. 2014 Mar 26;5:50. doi: 10.3389/fgene.2014.00050. eCollection 2014. Front Genet. 2014. PMID: 24723935 Free PMC article.
In Phase II, which began in 2011, genomic discovery efforts continue and in addition the network is investigating best practices for implementing genomic medicine, in particular, the return of genomic results in the EHR for use by …
In Phase II, which began in 2011, genomic discovery efforts continue and in addition the network is investigating best practic …
Harmonizing Clinical Sequencing and Interpretation for the eMERGE III Network.
eMERGE Consortium. Electronic address: agibbs@bcm.edu; eMERGE Consortium. eMERGE Consortium. Electronic address: agibbs@bcm.edu, et al. Am J Hum Genet. 2019 Sep 5;105(3):588-605. doi: 10.1016/j.ajhg.2019.07.018. Epub 2019 Aug 22. Am J Hum Genet. 2019. PMID: 31447099 Free PMC article.
The eMERGE III Network enrolled >25,000 participants from biobank and prospective cohorts of predominantly healthy individuals for clinical genetic testing to determine clinically actionable findings. ...This study accomplished integration of structured genomi
The eMERGE III Network enrolled >25,000 participants from biobank and prospective cohorts of predominantly healthy individu …
Physicians' perspectives on receiving unsolicited genomic results.
Pet DB, Holm IA, Williams JL, Myers MF, Novak LL, Brothers KB, Wiesner GL, Clayton EW. Pet DB, et al. Genet Med. 2019 Feb;21(2):311-318. doi: 10.1038/s41436-018-0047-z. Epub 2018 Jul 5. Genet Med. 2019. PMID: 29904163 Free PMC article.
PURPOSE: Physicians increasingly receive genomic test results they did not order, which we term "unsolicited genomic results" (UGRs). We asked physicians how they think such results will affect them and their patients. METHODS: Semistructured in …
PURPOSE: Physicians increasingly receive genomic test results they did not order, which we term "unsolicited genomic
Conducting a large, multi-site survey about patients' views on broad consent: challenges and solutions.
Smith ME, Sanderson SC, Brothers KB, Myers MF, McCormick J, Aufox S, Shrubsole MJ, Garrison NA, Mercaldo ND, Schildcrout JS, Clayton EW, Antommaria AH, Basford M, Brilliant M, Connolly JJ, Fullerton SM, Horowitz CR, Jarvik GP, Kaufman D, Kitchner T, Li R, Ludman EJ, McCarty C, McManus V, Stallings S, Williams JL, Holm IA. Smith ME, et al. BMC Med Res Methodol. 2016 Nov 24;16(1):162. doi: 10.1186/s12874-016-0263-7. BMC Med Res Methodol. 2016. PMID: 27881091 Free PMC article.
BACKGROUND: As biobanks play an increasing role in the genomic research that will lead to precision medicine, input from diverse and large populations of patients in a variety of health care settings will be important in order to successfully carry out such studies. …
BACKGROUND: As biobanks play an increasing role in the genomic research that will lead to precision medicine, input from diver …
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