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Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry.
Ding X, Chou B, Graham RA, Cheeti S, Percey S, Matassa LC, Reuschel SA, Meng M, Liu S, Voelker T, Lum BL, Rudewicz PJ, Hop CE. Ding X, et al. Among authors: reuschel sa. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Mar 15;878(9-10):785-90. doi: 10.1016/j.jchromb.2010.01.039. Epub 2010 Feb 1. J Chromatogr B Analyt Technol Biomed Life Sci. 2010. PMID: 20172765
A solid phase extraction-liquid chromatographic-tandem mass spectrometry method for determination of concentrations of GDC-0941, a small molecule class I phosphatidylinositide 3-kinase inhibitor, to support clinical development.
Ding X, Morrison G, Dean B, Hop CE, Tobler L, Percey S, Meng M, Reuschel S, West DA, Holden S, Ware JA. Ding X, et al. J Pharm Biomed Anal. 2012 Mar 5;61:1-7. doi: 10.1016/j.jpba.2011.11.005. Epub 2011 Nov 25. J Pharm Biomed Anal. 2012. PMID: 22169467 Clinical Trial.
Simultaneous quantitation of polymyxin B1, polymyxin B2 and polymyxin B1-1 in human plasma and treated human urine using solid phase extraction and liquid chromatography-tandem mass spectrometry.
Meng M, Wang L, Liu S, Jaber OM, Gao L, Chevrette L, Reuschel S. Meng M, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:23-36. doi: 10.1016/j.jchromb.2016.01.013. Epub 2016 Jan 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 26803416
23 results