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Page 1
Transcriptional regulation of disease-relevant microglial activation programs.
McQuade A, Mishra R, Hagan V, Liang W, Colias PJ, Castillo VC, Gonzalez B, Lubin JP, Haage V, Marshe V, Fujita M, Ta T, Gomes L, Teter O, Han X, Robichaud N, Chasins SE, Rexach JE, De Jager PL, Nuñez JK, Kampmann M. McQuade A, et al. Among authors: rexach je. Neuron. 2026 Jul 29:S0896-6273(26)00530-1. doi: 10.1016/j.neuron.2026.07.001. Online ahead of print. Neuron. 2026. PMID: 42526428 Free article.
An emergent disease-associated motor neuron state precedes cell death in ALS.
Gautier O, Blum JA, Nguyen TP, Cao S, Klemm S, Yamakawa M, Huh D, Hurt JA, Sinnott-Armstrong N, Zeng Y, Davis CO, Bombosch J, Liu C, Encarnacion LN, Guttenplan KA, Chen D, Kathiria A, Zhao L, Moore S, Meng A, Ong K, Cleveland DW, Ravits J, Rexach JE, Greenleaf WJ, Gitler AD. Gautier O, et al. Among authors: rexach je. Cell. 2026 Aug 6;189(16):5044-5064.e12. doi: 10.1016/j.cell.2026.05.047. Epub 2026 Jun 23. Cell. 2026. PMID: 42335888 Free PMC article.
Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimer's disease.
Pereira FL, Lew C, Li SH, Rizzi L, Soloviev AV, Paes V, Brooks SD, Spina S, Rexach JE, Newell KL, Leite REP, Seeley WW, Suemoto CK, Ghetti B, Murray ME, Grinberg LT. Pereira FL, et al. Among authors: rexach je. bioRxiv [Preprint]. 2026 Apr 1:2026.03.30.715299. doi: 10.64898/2026.03.30.715299. bioRxiv. 2026. PMID: 41959086 Free PMC article. Preprint.
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Bose RS, Travaglini KJ, Lam VL, Goodness D, Ta T, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan HS, Carroll EC, Lawrence RE, Gestwicki JE, Rexach JE, Eisenberg DS, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M. Samelson AJ, et al. Among authors: rexach je. Cell. 2026 Mar 5;189(5):1517-1534.e19. doi: 10.1016/j.cell.2025.12.038. Epub 2026 Jan 28. Cell. 2026. PMID: 41610849 Free PMC article.
Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain.
Chaubey K, Vázquez-Rosa E, Tripathi SJ, Shin MK, Yu Y, Dhar M, Chakraborty S, Yamakawa M, Wang X, Sridharan PS, Miller E, Bud Z, Corella SG, Barker S, Caradonna SG, Koh Y, Franke K, Cintrón-Pérez CJ, Rose S, Fang H, Cintrón-Pérez AA, Tomco T, Zhu X, Fujioka H, Gefen T, Flanagan ME, Williams NS, Wilson BM, Chen L, Dou L, Cheng F, Rexach JE, Woo JA, Kang DE, Paul BD, Pieper AA. Chaubey K, et al. Among authors: rexach je. Cell Rep Med. 2026 Jan 20;7(1):102535. doi: 10.1016/j.xcrm.2025.102535. Epub 2025 Dec 22. Cell Rep Med. 2026. PMID: 41435831 Free PMC article.
An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS.
Gautier O, Blum JA, Nguyen TP, Klemm S, Yamakawa M, Sinnott-Armstrong N, Zeng Y, Davis CO, Bombosch J, Nakayama L, Guttenplan KA, Chen D, Kathira A, Zhao L, Rexach JE, Greenleaf WJ, Gitler AD. Gautier O, et al. Among authors: rexach je. bioRxiv [Preprint]. 2025 Aug 25:2025.08.21.671404. doi: 10.1101/2025.08.21.671404. bioRxiv. 2025. Update in: Cell. 2026 Aug 6;189(16):5044-5064.e12. doi: 10.1016/j.cell.2026.05.047. PMID: 40909710 Free PMC article. Updated. Preprint.
BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults.
Cadwallader CJ, VandeBunte AM, Fischer DL, Chen C, Diaz VE, Lee SY, Chan B, Lario-Lago A, Rojas JC, Ramos EM, Rexach JE, Yokoyama JS, Kramer JH, Paolillo EW, Saloner R, Casaletto KB. Cadwallader CJ, et al. Among authors: rexach je. Alzheimers Dement (N Y). 2025 Jun 19;11(2):e70106. doi: 10.1002/trc2.70106. eCollection 2025 Apr-Jun. Alzheimers Dement (N Y). 2025. PMID: 40547329 Free PMC article.
Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states.
Han X, Zhang T, Lee CY, Ravi A, Spina S, Li AN, Grinberg LT, Seeley WW, Huckins LM, Raj T, Brennand KJ, Rexach JE. Han X, et al. Among authors: rexach je. bioRxiv [Preprint]. 2025 Jun 4:2025.06.02.657512. doi: 10.1101/2025.06.02.657512. bioRxiv. 2025. Update in: Nat Commun. 2026 May 14;17(1):6439. doi: 10.1038/s41467-026-73007-1. PMID: 40502140 Free PMC article. Updated. Preprint.
Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.
Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S, Da Mesquita S, Dabin LC, Devanand D, Duran-Laforet V, Elyaman W, Evans EE, Fitzgerald-Bocarsly P, Foley KE, Harms AS, Heneka MT, Hong S, Huang YA, Jackvony S, Lai L, Guen YL, Lemere CA, Liddelow SA, Martin-Peña A, Orr AG, Quintana FJ, Ramey GD, Rexach JE, Rizzo SJS, Sexton C, Tang AS, Torrellas JG, Tsai AP, van Olst L, Walker KA, Wharton W, Tansey MG, Wilcock DM. Kloske CM, et al. Among authors: rexach je. Alzheimers Dement. 2025 Jan;21(1):e14291. doi: 10.1002/alz.14291. Epub 2024 Dec 18. Alzheimers Dement. 2025. PMID: 39692624 Free PMC article. Review.
32 results