Reyes A - Search Results

1

Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies.

Sun LL, Ellerman D, Mathieu M, Hristopoulos M, Chen X, Li Y, Yan X, Clark R, Reyes A, Stefanich E, Mai E, Young J, Johnson C, Huseni M, Wang X, Chen Y, Wang P, Wang H, Dybdal N, Chu YW, Chiorazzi N, Scheer JM, Junttila T, Totpal K, Dennis MS, Ebens AJ. Sun LL, et al. Among authors: reyes a. Sci Transl Med. 2015 May 13;7(287):287ra70. doi: 10.1126/scitranslmed.aaa4802. Sci Transl Med. 2015. PMID: 25972002

2

A Preclinical Population Pharmacokinetic Model for Anti-CD20/CD3 T-Cell-Dependent Bispecific Antibodies.

Ferl GZ, Reyes A, Sun LL, Cheu M, Oldendorp A, Ramanujan S, Stefanich EG. Ferl GZ, et al. Among authors: reyes a. Clin Transl Sci. 2018 May;11(3):296-304. doi: 10.1111/cts.12535. Epub 2018 Jan 19. Clin Transl Sci. 2018. PMID: 29351372 Free PMC article.

3

Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies.

Yadav R, Sukumaran S, Zabka TS, Li J, Oldendorp A, Morrow G, Reyes A, Cheu M, Li J, Wallin JJ, Tsai S, Sun L, Wang P, Ellerman D, Spiess C, Polson A, Stefanich EG, Kamath AV, Ovacik MA. Yadav R, et al. Among authors: reyes a. Pharmaceutics. 2022 Apr 30;14(5):970. doi: 10.3390/pharmaceutics14050970. Pharmaceutics. 2022. PMID: 35631556 Free PMC article.

4

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4.

Bumbaca D, Wong A, Drake E, Reyes AE 2nd, Lin BC, Stephan JP, Desnoyers L, Shen BQ, Dennis MS. Bumbaca D, et al. Among authors: reyes ae 2nd. MAbs. 2011 Jul-Aug;3(4):376-86. doi: 10.4161/mabs.3.4.15786. Epub 2011 Jul 1. MAbs. 2011. PMID: 21540647 Free PMC article.

5

The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin.

Nguyen A, Reyes AE 2nd, Zhang M, McDonald P, Wong WL, Damico LA, Dennis MS. Nguyen A, et al. Among authors: reyes ae 2nd. Protein Eng Des Sel. 2006 Jul;19(7):291-7. doi: 10.1093/protein/gzl011. Epub 2006 Apr 18. Protein Eng Des Sel. 2006. PMID: 16621915

6

Onartuzumab (MetMAb): using nonclinical pharmacokinetic and concentration-effect data to support clinical development.

Xiang H, Bender BC, Reyes AE 2nd, Merchant M, Jumbe NL, Romero M, Davancaze T, Nijem I, Mai E, Young J, Peterson A, Damico-Beyer LA. Xiang H, et al. Among authors: reyes ae 2nd. Clin Cancer Res. 2013 Sep 15;19(18):5068-78. doi: 10.1158/1078-0432.CCR-13-0260. Epub 2013 Jul 26. Clin Cancer Res. 2013. PMID: 23894056

7

A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life.

Yeung YA, Wu X, Reyes AE 2nd, Vernes JM, Lien S, Lowe J, Maia M, Forrest WF, Meng YG, Damico LA, Ferrara N, Lowman HB. Yeung YA, et al. Among authors: reyes ae 2nd. Cancer Res. 2010 Apr 15;70(8):3269-77. doi: 10.1158/0008-5472.CAN-09-4580. Epub 2010 Mar 30. Cancer Res. 2010. PMID: 20354184

8

Complex formation of anti-VEGF-C with VEGF-C released during blood coagulation resulted in an artifact in its serum pharmacokinetics.

Bumbaca Yadav D, Reyes AE 2nd, Gupta P, Vernes JM, Meng YG, Schweiger MG, Stainton SL, Fuh G, Fielder PJ, Kamath AV, Shen BQ. Bumbaca Yadav D, et al. Pharmacol Res Perspect. 2020 Apr;8(2):e00573. doi: 10.1002/prp2.573. Pharmacol Res Perspect. 2020. PMID: 32125783 Free PMC article.

9

Death receptor 5 agonistic antibody PRO95780: preclinical pharmacokinetics and concentration-effect relationship support clinical dose and regimen selection.

Xiang H, Reyes AE 2nd, Eppler S, Kelley S, Damico-Beyer LA. Xiang H, et al. Among authors: reyes ae 2nd. Cancer Chemother Pharmacol. 2013 Aug;72(2):405-15. doi: 10.1007/s00280-013-2200-3. Epub 2013 Jun 16. Cancer Chemother Pharmacol. 2013. PMID: 23771513

10

Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.

Rajapaksa KS, Huang T, Sharma N, Liu S, Solon M, Reyes A, Paul S, Yee A, Tao J, Chalasani S, Bien-Ly N, Barck K, Carano RA, Wang J, Rangell L, Bremer M, Danilenko DM, Katavolos P, Hotzel I, Reif K, Austin CD. Rajapaksa KS, et al. Among authors: reyes a. Toxicol Sci. 2016 Jul;152(1):72-84. doi: 10.1093/toxsci/kfw067. Epub 2016 Apr 21. Toxicol Sci. 2016. PMID: 27103662

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