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Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.
Tovy A, Reyes JM, Gundry MC, Brunetti L, Lee-Six H, Petljak M, Park HJ, Guzman AG, Rosas C, Jeffries AR, Baple E, Mill J, Crosby AH, Sency V, Xin B, Machado HE, Castillo D, Weitzel JN, Li W, Stratton MR, Campbell PJ, Wang H, Sanders MA, Goodell MA. Tovy A, et al. Among authors: reyes jm. Cell Stem Cell. 2020 Aug 6;27(2):326-335.e4. doi: 10.1016/j.stem.2020.06.018. Epub 2020 Jul 15. Cell Stem Cell. 2020. PMID: 32673568 Free PMC article.
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo.
Jeong M, Park HJ, Celik H, Ostrander EL, Reyes JM, Guzman A, Rodriguez B, Lei Y, Lee Y, Ding L, Guryanova OA, Li W, Goodell MA, Challen GA. Jeong M, et al. Among authors: reyes jm. Cell Rep. 2018 Apr 3;23(1):1-10. doi: 10.1016/j.celrep.2018.03.025. Cell Rep. 2018. PMID: 29617651 Free PMC article.
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.
Sportoletti P, Sorcini D, Guzman AG, Reyes JM, Stella A, Marra A, Sartori S, Brunetti L, Rossi R, Papa BD, Adamo FM, Pianigiani G, Betti C, Scialdone A, Guarente V, Spinozzi G, Tini V, Martelli MP, Goodell MA, Falini B. Sportoletti P, et al. Among authors: reyes jm. Leukemia. 2021 Jul;35(7):1949-1963. doi: 10.1038/s41375-020-01075-3. Epub 2020 Nov 6. Leukemia. 2021. PMID: 33159179 Free PMC article.
Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
Tovy A, Rosas C, Gaikwad AS, Medrano G, Zhang L, Reyes JM, Huang YH, Arakawa T, Kurtz K, Conneely SE, Guzman AG, Aguilar R, Gao A, Chen CW, Kim JJ, Carter MT, Lasa-Aranzasti A, Valenzuela I, Van Maldergem L, Brunetti L, Hicks MJ, Marcogliese AN, Goodell MA, Rau RE. Tovy A, et al. Among authors: reyes jm. Haematologica. 2022 Apr 1;107(4):887-898. doi: 10.3324/haematol.2021.278990. Haematologica. 2022. PMID: 34092059 Free PMC article.
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
Huang YH, Chen CW, Sundaramurthy V, Słabicki M, Hao D, Watson CJ, Tovy A, Reyes JM, Dakhova O, Crovetti BR, Galonska C, Lee M, Brunetti L, Zhou Y, Tatton-Brown K, Huang Y, Cheng X, Meissner A, Valk PJM, Van Maldergem L, Sanders MA, Blundell JR, Li W, Ebert BL, Goodell MA. Huang YH, et al. Among authors: reyes jm. Cancer Discov. 2022 Jan;12(1):220-235. doi: 10.1158/2159-8290.CD-21-0560. Epub 2021 Aug 24. Cancer Discov. 2022. PMID: 34429321 Free PMC article.
Modeling IKZF1 lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities.
Rogers JH, Gupta R, Reyes JM, Gundry MC, Medrano G, Guzman A, Aguilar R, Conneely SE, Song T, Johnson C, Barnes S, Cristobal CDD, Kurtz K, Brunetti L, Goodell MA, Rau RE. Rogers JH, et al. Among authors: reyes jm. Blood Adv. 2021 Oct 12;5(19):3876-3890. doi: 10.1182/bloodadvances.2020002408. Blood Adv. 2021. PMID: 34492683 Free PMC article.
Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis.
Tovy A, Reyes JM, Zhang L, Huang YH, Rosas C, Daquinag AC, Guzman A, Ramabadran R, Chen CW, Gu T, Gupta S, Ortinau L, Park D, Cox AR, Rau RE, Hartig SM, Kolonin MG, Goodell MA. Tovy A, et al. Among authors: reyes jm. Elife. 2022 May 30;11:e72359. doi: 10.7554/eLife.72359. Elife. 2022. PMID: 35635747 Free PMC article.
DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells.
Ramabadran R, Wang JH, Reyes JM, Guzman AG, Gupta S, Rosas C, Brunetti L, Gundry MC, Tovy A, Long H, Gu T, Cullen SM, Tyagi S, Rux D, Kim JJ, Kornblau SM, Kyba M, Stossi F, Rau RE, Takahashi K, Westbrook TF, Goodell MA. Ramabadran R, et al. Among authors: reyes jm. Nat Cell Biol. 2023 Apr;25(4):528-539. doi: 10.1038/s41556-023-01109-9. Epub 2023 Apr 6. Nat Cell Biol. 2023. PMID: 37024683 Free PMC article.
130 results