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The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.
Arena C, Gado F, Di Cesare Mannelli L, Cervetto C, Carpi S, Reynoso-Moreno I, Polini B, Vallini E, Chicca S, Lucarini E, Bertini S, D'Andrea F, Digiacomo M, Poli G, Tuccinardi T, Macchia M, Gertsch J, Marcoli M, Nieri P, Ghelardini C, Chicca A, Manera C. Arena C, et al. Among authors: reynoso moreno i. Eur J Med Chem. 2020 Dec 15;208:112858. doi: 10.1016/j.ejmech.2020.112858. Epub 2020 Sep 29. Eur J Med Chem. 2020. PMID: 33002735
Assay of Endocannabinoid Uptake.
Reynoso-Moreno I, Rau M, Chicca A, Nicolussi S, Gertsch J. Reynoso-Moreno I, et al. Methods Mol Biol. 2023;2576:329-348. doi: 10.1007/978-1-0716-2728-0_28. Methods Mol Biol. 2023. PMID: 36152200
Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.
Chicca A, Nicolussi S, Bartholomäus R, Blunder M, Aparisi Rey A, Petrucci V, Reynoso-Moreno IDC, Viveros-Paredes JM, Dalghi Gens M, Lutz B, Schiöth HB, Soeberdt M, Abels C, Charles RP, Altmann KH, Gertsch J. Chicca A, et al. Among authors: reynoso moreno idc. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E5006-E5015. doi: 10.1073/pnas.1704065114. Epub 2017 Jun 5. Proc Natl Acad Sci U S A. 2017. PMID: 28584105 Free PMC article.
Δ9-cis-Tetrahydrocannabinol: Natural Occurrence, Chirality, and Pharmacology.
Schafroth MA, Mazzoccanti G, Reynoso-Moreno I, Erni R, Pollastro F, Caprioglio D, Botta B, Allegrone G, Grassi G, Chicca A, Gasparrini F, Gertsch J, Carreira EM, Appendino G. Schafroth MA, et al. Among authors: reynoso moreno i. J Nat Prod. 2021 Sep 24;84(9):2502-2510. doi: 10.1021/acs.jnatprod.1c00513. Epub 2021 Jul 25. J Nat Prod. 2021. PMID: 34304557 Free article.