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The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.
Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov LR, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Wohlford-Lenane C, Taft PJ, Rector MV, Hornick E, Nassar BS, Samuel M, Zhang Y, Richter SS, Uc A, Shilyansky J, Prather RS, McCray PB Jr, Zabner J, Welsh MJ, Stoltz DA. Ostedgaard LS, et al. Among authors: reznikov lr. Sci Transl Med. 2011 Mar 16;3(74):74ra24. doi: 10.1126/scitranslmed.3001868. Sci Transl Med. 2011. PMID: 21411740 Free PMC article.
Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis.
Chang EH, Pezzulo AA, Meyerholz DK, Potash AE, Wallen TJ, Reznikov LR, Sieren JC, Karp PH, Ernst S, Moninger TO, Gansemer ND, McCray PB Jr, Stoltz DA, Welsh MJ, Zabner J. Chang EH, et al. Among authors: reznikov lr. Laryngoscope. 2012 Sep;122(9):1898-905. doi: 10.1002/lary.23392. Epub 2012 Jun 18. Laryngoscope. 2012. PMID: 22711071 Free PMC article.
CFTR-deficient pigs display peripheral nervous system defects at birth.
Reznikov LR, Dong Q, Chen JH, Moninger TO, Park JM, Zhang Y, Du J, Hildebrand MS, Smith RJ, Randak CO, Stoltz DA, Welsh MJ. Reznikov LR, et al. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3083-8. doi: 10.1073/pnas.1222729110. Epub 2013 Feb 4. Proc Natl Acad Sci U S A. 2013. PMID: 23382208 Free PMC article.
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Abou Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ, Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson GA 4th, Hoffman EA, Chang EH, Zabner J, McCray PB Jr, Prather RS, Meyerholz DK, Welsh MJ. Stoltz DA, et al. Among authors: reznikov lr. J Clin Invest. 2013 Jun;123(6):2685-93. doi: 10.1172/JCI68867. Epub 2013 May 8. J Clin Invest. 2013. PMID: 23676501 Free PMC article.
Antibacterial properties of the CFTR potentiator ivacaftor.
Reznikov LR, Abou Alaiwa MH, Dohrn CL, Gansemer ND, Diekema DJ, Stoltz DA, Welsh MJ. Reznikov LR, et al. J Cyst Fibros. 2014 Sep;13(5):515-9. doi: 10.1016/j.jcf.2014.02.004. Epub 2014 Mar 5. J Cyst Fibros. 2014. PMID: 24618508 Free PMC article.
Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass.
Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW. Uc A, et al. Among authors: reznikov lr. Clin Sci (Lond). 2015 Jan;128(2):131-42. doi: 10.1042/CS20140059. Clin Sci (Lond). 2015. PMID: 25142104 Free PMC article.
59 results