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Page 1
CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice.
Hammerschmidt P, Steculorum SM, Bandet CL, Del Río-Martín A, Steuernagel L, Kohlhaas V, Feldmann M, Varela L, Majcher A, Quatorze Correia M, Klar RFU, Bauder CA, Kaya E, Porniece M, Biglari N, Sieben A, Horvath TL, Hornemann T, Brodesser S, Brüning JC. Hammerschmidt P, et al. Among authors: klar rfu. Nat Commun. 2023 Nov 29;14(1):7824. doi: 10.1038/s41467-023-42595-7. Nat Commun. 2023. PMID: 38016943 Free PMC article.
BRAFΔβ3-αC in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability.
Lauinger M, Christen D, Klar RFU, Roubaty C, Heilig CE, Stumpe M, Knox JJ, Radulovich N, Tamblyn L, Xie IY, Horak P, Forschner A, Bitzer M, Wittel UA, Boerries M, Ball CR, Heining C, Glimm H, Fröhlich M, Hübschmann D, Gallinger S, Fritsch R, Fröhling S, O'Kane GM, Dengjel J, Brummer T. Lauinger M, et al. Among authors: klar rfu. Sci Adv. 2023 Sep;9(35):eade7486. doi: 10.1126/sciadv.ade7486. Epub 2023 Sep 1. Sci Adv. 2023. PMID: 37656784 Free PMC article.
Coordination of cytochrome bc1 complex assembly at MICOS.
Zerbes RM, Colina-Tenorio L, Bohnert M, von der Malsburg K, Peikert CD, Mehnert CS, Perschil I, Klar RFU, de Boer R, Kram A, van der Klei I, Oeljeklaus S, Warscheid B, Rampelt H, van der Laan M. Zerbes RM, et al. Among authors: klar rfu. EMBO Rep. 2025 Jan;26(2):353-384. doi: 10.1038/s44319-024-00336-x. Epub 2024 Dec 2. EMBO Rep. 2025. PMID: 39623166 Free PMC article.
Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition.
Catalano A, Adlesic M, Kaltenbacher T, Klar RFU, Albers J, Seidel P, Brandt LP, Hejhal T, Busenhart P, Röhner N, Zodel K, Fritsch K, Wild PJ, Duyster J, Fritsch R, Brummer T, Frew IJ. Catalano A, et al. Among authors: klar rfu. Cancers (Basel). 2021 Apr 13;13(8):1852. doi: 10.3390/cancers13081852. Cancers (Basel). 2021. PMID: 33924486 Free PMC article.
Development and Clinical Validation of Discriminatory Multitarget Digital Droplet PCR Assays for the Detection of Hot Spot KRAS and NRAS Mutations in Cell-Free DNA.
Hussung S, Follo M, Klar RFU, Michalczyk S, Fritsch K, Nollmann F, Hipp J, Duyster J, Scherer F, von Bubnoff N, Boerries M, Wittel U, Fritsch RM. Hussung S, et al. Among authors: klar rfu. J Mol Diagn. 2020 Jul;22(7):943-956. doi: 10.1016/j.jmoldx.2020.04.206. Epub 2020 May 4. J Mol Diagn. 2020. PMID: 32376474 Free article.