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Showing results for rho rock pten.
Search for Rho Rocks PTEN. instead (1 results)
The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behavior.
Yang S, Kim HM. Yang S, et al. Biomaterials. 2012 Apr;33(10):2902-15. doi: 10.1016/j.biomaterials.2011.12.051. Epub 2012 Jan 13. Biomaterials. 2012. PMID: 22244698
The high RhoA activity in the cells poorly attached to substrates caused an increase in the activity of Rho-associated kinase (ROCK), a well-known effector of RhoA that upregulated the activity of phosphatase and tensin homolog (PTEN). ...Based on these resul …
The high RhoA activity in the cells poorly attached to substrates caused an increase in the activity of Rho-associated kinase (ROC …
Regulation of PTEN by Rho small GTPases.
Li Z, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D. Li Z, et al. Nat Cell Biol. 2005 Apr;7(4):399-404. doi: 10.1038/ncb1236. Epub 2005 Mar 27. Nat Cell Biol. 2005. PMID: 15793569
However, the mechanisms for its regulation remain elusive. Here we show that RhoA and Cdc42, members of the Rho family of small GTPases, regulate the intracellular localization of PTEN in leukocytes and human transfected embryonic kidney cells. In addition, active R …
However, the mechanisms for its regulation remain elusive. Here we show that RhoA and Cdc42, members of the Rho family of small GTPas …
The double face of Morgana in tumorigenesis.
Brancaccio M, Rocca S, Seclì L, Busso E, Fusella F. Brancaccio M, et al. Oncotarget. 2015 Dec 15;6(40):42603-12. doi: 10.18632/oncotarget.6058. Oncotarget. 2015. PMID: 26460959 Free PMC article. Review.
Morgana is a chaperone protein able to bind to ROCK I and II and to inhibit their kinase activity. Rho kinases are multifunctional proteins involved in different cellular processes, including cytoskeleton organization, centrosome duplication, cell survival and proli …
Morgana is a chaperone protein able to bind to ROCK I and II and to inhibit their kinase activity. Rho kinases are multifuncti …
Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.
Fusella F, Ferretti R, Recupero D, Rocca S, Di Savino A, Tornillo G, Silengo L, Turco E, Cabodi S, Provero P, Pandolfi PP, Sapino A, Tarone G, Brancaccio M. Fusella F, et al. J Pathol. 2014 Oct;234(2):152-63. doi: 10.1002/path.4341. Epub 2014 Aug 6. J Pathol. 2014. PMID: 24615293
From a mechanistic point of view, we demonstrate that morgana causes PTEN destabilization, by inhibiting ROCK activity, hence triggering the PI3K/AKT survival pathway. In turn, morgana down-regulation in breast cancer cells that express high morgana levels increases …
From a mechanistic point of view, we demonstrate that morgana causes PTEN destabilization, by inhibiting ROCK activity, hence …
Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors.
Guan R, Xu X, Chen M, Hu H, Ge H, Wen S, Zhou S, Pi R. Guan R, et al. Eur J Med Chem. 2013;70:613-22. doi: 10.1016/j.ejmech.2013.10.048. Epub 2013 Oct 25. Eur J Med Chem. 2013. PMID: 24211637 Review.
The pathway is also involved in the development of many diseases such as vasospasm, pulmonary hypertension, cancer and central nervous systems (CNS) disorders. The inhibitors of Rho kinase have been extensively studied since the Rho/Rho-kinase pathway was ver …
The pathway is also involved in the development of many diseases such as vasospasm, pulmonary hypertension, cancer and central nervous syste …
Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain.
Wu J, Li J, Hu H, Liu P, Fang Y, Wu D. Wu J, et al. Cell Mol Neurobiol. 2012 Oct;32(7):1187-97. doi: 10.1007/s10571-012-9845-z. Epub 2012 May 3. Cell Mol Neurobiol. 2012. PMID: 22552888
In this study, we determined whether ROCK inhibitor, fasudil, inhibited ischemic neuronal apoptosis through phosphatase and tensin homolog deleted on chromosome10 (PTEN)/Akt/signal pathway in vivo. ...In conclusion, the findings provide another consideration that fa …
In this study, we determined whether ROCK inhibitor, fasudil, inhibited ischemic neuronal apoptosis through phosphatase and tensin ho …
Hypoxia-induced ARHGAP26 deficiency inhibits the proliferation and migration of human ductus arteriosus smooth muscle cell through activating RhoA-ROCK-PTEN pathway.
Li M, Ye L, Ye X, Wang S, Zhang H, Liu J, Hong H. Li M, et al. J Cell Biochem. 2019 Jun;120(6):10106-10117. doi: 10.1002/jcb.28294. Epub 2018 Dec 28. J Cell Biochem. 2019. PMID: 30592323
Rho GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein for the small GTPases of the Rho family. ...Use of Y27632, an inhibitor of ROCK which further reduces the phospholipid activity of PTEN can reverse the inhibitory effect of P …
Rho GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein for the small GTPases of the Rho family. ...Use of …
RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.
Li G, Liu L, Shan C, Cheng Q, Budhraja A, Zhou T, Cui H, Gao N. Li G, et al. Cell Death Dis. 2014 Jan 16;5(1):e998. doi: 10.1038/cddis.2013.519. Cell Death Dis. 2014. PMID: 24434521 Free PMC article.
This increase was accompanied by the activation of caspases, cytochrome c release, Bcl2-associated X protein (Bax) translocation, myeloid cell leukemia-1 (Mcl-1) downregulation, Bcl-2-associated death promoter (Bad) dephosphorylation, Akt inactivation, and RhoA/Rho-associa …
This increase was accompanied by the activation of caspases, cytochrome c release, Bcl2-associated X protein (Bax) translocation, myeloid ce …
Rho GTPases in primary brain tumor malignancy and invasion.
Khalil BD, El-Sibai M. Khalil BD, et al. J Neurooncol. 2012 Jul;108(3):333-9. doi: 10.1007/s11060-012-0866-8. Epub 2012 Apr 19. J Neurooncol. 2012. PMID: 22528793 Review.
Here we review the suggested effects of deregulated Rho GTPase signaling on brain tumor malignancy, highlighting the controversy in the field. ...In addition to the Rho GTPases themselves, several of their downstream effectors (including ROCK, mDia, and N-WAS …
Here we review the suggested effects of deregulated Rho GTPase signaling on brain tumor malignancy, highlighting the controversy in t …
Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1.
Mu D, Zhou G, Li J, Su B, Guo H. Mu D, et al. Oncol Lett. 2018 Mar;15(3):3202-3206. doi: 10.3892/ol.2017.7689. Epub 2017 Dec 27. Oncol Lett. 2018. PMID: 29435058 Free PMC article.
The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role i …
The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism …
44 results