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Intra-luminal nicotine reduces smooth muscle tone and contractile activity in the distal large bowel.
Green JT, McKirdy HC, Rhodes J, Thomas GA, Evans BK. Green JT, et al. Eur J Gastroenterol Hepatol. 1999 Nov;11(11):1299-304. doi: 10.1097/00042737-199911000-00020. Eur J Gastroenterol Hepatol. 1999. PMID: 10563544 Clinical Trial.
A randomized trial of nicotine enemas for active ulcerative colitis.
Ingram JR, Thomas GA, Rhodes J, Green JT, Hawkes ND, Swift JL, Srivastava ED, Evans BK, Williams GT, Newcombe RG, Courtney E, Pillai S. Ingram JR, et al. Clin Gastroenterol Hepatol. 2005 Nov;3(11):1107-14. doi: 10.1016/s1542-3565(05)00849-9. Clin Gastroenterol Hepatol. 2005. PMID: 16271342 Clinical Trial.
Successful treatment of pyoderma gangrenosum with topical 0.5% nicotine cream.
Patel GK, Rhodes JR, Evans B, Holt PJ. Patel GK, et al. J Dermatolog Treat. 2004 Apr;15(2):122-5. doi: 10.1080/09546630310019364. J Dermatolog Treat. 2004. PMID: 15204166
Is transdermal nicotine associated with cardiovascular risk?
Thomas GA, Davies SV, Rhodes J, Russell MA, Feyerabend C, Säwe U. Thomas GA, et al. J R Coll Physicians Lond. 1995 Sep-Oct;29(5):392-6. J R Coll Physicians Lond. 1995. PMID: 8847680 Free PMC article. Clinical Trial.
Smoking and ulcerative colitis: a community study.
Srivasta ED, Newcombe RG, Rhodes J, Avramidis P, Mayberry JF. Srivasta ED, et al. Int J Colorectal Dis. 1993 Jul;8(2):71-4. doi: 10.1007/BF00299330. Int J Colorectal Dis. 1993. PMID: 8409689
Nicotine enemas for active Crohn's colitis: an open pilot study.
Ingram JR, Rhodes J, Evans BK, Thomas GA. Ingram JR, et al. Gastroenterol Res Pract. 2008;2008:237185. doi: 10.1155/2008/237185. Gastroenterol Res Pract. 2008. PMID: 18795117 Free PMC article.
Nitric oxide mediates a therapeutic effect of nicotine in ulcerative colitis.
Green JT, Richardson C, Marshall RW, Rhodes J, McKirdy HC, Thomas GA, Williams GT. Green JT, et al. Aliment Pharmacol Ther. 2000 Nov;14(11):1429-34. doi: 10.1046/j.1365-2036.2000.00847.x. Aliment Pharmacol Ther. 2000. PMID: 11069313
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