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Table representation of search results timeline featuring number of search results per year.

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1995 1
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2000 5
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2006 8
2007 3
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215 results
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Filters applied: . Clear all The following terms were not found in PubMed: OsMAP65-3.1, OsMAP65-3.2
Page 1
New insights into the genetic etiology of Alzheimer's disease and related dementias.
Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarcón-Martín E, Alcolea D, Alegret M, Alvarez I, Álvarez V, Armstrong NJ, Tsolaki A, Antúnez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bailly H, Banaj N, Baquero M, Barral S, Beiser A, Pastor AB, Below JE, Benchek P, Benussi L, Berr C, Besse C, Bessi V, Binetti G, Bizarro A, Blesa R, Boada M, Boerwinkle E, Borroni B, Boschi S, Bossù P, Bråthen G, Bressler J, Bresner C, Brodaty H, Brookes KJ, Brusco LI, Buiza-Rueda D, Bûrger K, Burholt V, Bush WS, Calero M, Cantwell LB, Chene G, Chung J, Cuccaro ML, Carracedo Á, Cecchetti R, Cervera-Carles L, Charbonnier C, Chen HH, Chillotti C, Ciccone S, Claassen JAHR, Clark C, Conti E, Corma-Gómez A, Costantini E, Custodero C, Daian D, Dalmasso MC, Daniele A, Dardiotis E, Dartigues JF, de Deyn PP, de Paiva Lopes K, de Witte LD, Debette S, Deckert J, Del Ser T, Denning N, DeStefano A, Dichgans M,… See abstract for full author list ➔ Bellenguez C, et al. Nat Genet. 2022 Apr;54(4):412-436. doi: 10.1038/s41588-022-01024-z. Epub 2022 Apr 4. Nat Genet. 2022. PMID: 35379992 Free PMC article.
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. ...We also built a new genetic risk score associated wit …
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a …
Rice microtubule-associated protein OsMAP65-3.1, but not OsMAP65-3.2, plays a critical role in phragmoplast microtubule organization in cytokinesis.
Lin X, Xiao Y, Song Y, Gan C, Deng X, Wang P, Liu J, Jiang Z, Peng L, Zhou D, He X, Bian J, Zhu C, Liu B, He H, Xu J. Lin X, et al. Front Plant Sci. 2022 Oct 26;13:1030247. doi: 10.3389/fpls.2022.1030247. eCollection 2022. Front Plant Sci. 2022. PMID: 36388546 Free PMC article.
In plants, MAP65 preferentially cross-links the anti-parallel microtubules (MTs) and plays an important role for cytokinesis. However, the functions of MAP65 isoforms in rice (Oryza sativa. L) are largely unknown. Here, we identified two MAP65-3 homolo …
In plants, MAP65 preferentially cross-links the anti-parallel microtubules (MTs) and plays an important role for cytokinesis. …
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
BACKGROUND: Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease. METHODS: We conducted two double-blind, randomized, placebo-controlled, phase 3 trials involving patients with mild-to-moderate …
BACKGROUND: Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's …
Large-scale discovery of novel genetic causes of developmental disorders.
Deciphering Developmental Disorders Study. Deciphering Developmental Disorders Study. Nature. 2015 Mar 12;519(7542):223-8. doi: 10.1038/nature14135. Epub 2014 Dec 24. Nature. 2015. PMID: 25533962 Free PMC article.
By studying 1,133 children with severe, undiagnosed developmental disorders, and their parents, using a combination of exome sequencing and array-based detection of chromosomal rearrangements, we discovered 12 novel genes associated with developmental disorders. These newl …
By studying 1,133 children with severe, undiagnosed developmental disorders, and their parents, using a combination of exome sequencing and …
An evolutionarily conserved C4HC3-type E3 ligase regulates plant broad-spectrum resistance against pathogens.
Fu S, Wang K, Ma T, Liang Y, Ma Z, Wu J, Xu Y, Zhou X. Fu S, et al. Plant Cell. 2022 Apr 26;34(5):1822-1843. doi: 10.1093/plcell/koac055. Plant Cell. 2022. PMID: 35171277 Free PMC article.
Deployment of broad-spectrum disease resistance against multiple pathogen species is an efficient way to control plant diseases. Here, we identify a Microtubule-associated C4HC3-type E3 Ligase (MEL) in both Nicotiana benthamiana and Oryza sativa, and show tha …
Deployment of broad-spectrum disease resistance against multiple pathogen species is an efficient way to control plant diseases. Here, we id …
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective.
Derry PJ, Hegde ML, Jackson GR, Kayed R, Tour JM, Tsai AL, Kent TA. Derry PJ, et al. Prog Neurobiol. 2020 Jan;184:101716. doi: 10.1016/j.pneurobio.2019.101716. Epub 2019 Oct 8. Prog Neurobiol. 2020. PMID: 31604111 Free PMC article. Review.
The complexity of Alzheimer's disease (AD) complicates the search for effective treatments. While the key roles of pathologically modified proteins has occupied a central role in hypotheses of the pathophysiology, less attention has been paid to the potential …
The complexity of Alzheimer's disease (AD) complicates the search for effective treatments. While the key roles of pathologically mod …
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Capano LS, Sato C, Ficulle E, Yu A, Horie K, Kwon JS, Burbach KF, Barthélemy NR, Fox SG, Karch CM, Bateman RJ, Houlden H, Morimoto RI, Holtzman DM, Duff KE, Yoo AS. Capano LS, et al. Cell Stem Cell. 2022 Jun 2;29(6):918-932.e8. doi: 10.1016/j.stem.2022.04.018. Cell Stem Cell. 2022. PMID: 35659876
Tau is a microtubule-binding protein expressed in neurons, and the equal ratios between 4-repeat (4R) and 3-repeat (3R) isoforms are maintained in normal adult brain function. ...We carried out extensive characterizations of tau isoforms expressed in human neurons d …
Tau is a microtubule-binding protein expressed in neurons, and the equal ratios between 4-repeat (4R) and 3-repeat (3R) isofor …
CLASPs at a glance.
Lawrence EJ, Zanic M, Rice LM. Lawrence EJ, et al. J Cell Sci. 2020 Apr 24;133(8):jcs243097. doi: 10.1242/jcs.243097. J Cell Sci. 2020. PMID: 32332092 Free PMC article. Review.
CLIP-associating proteins (CLASPs) form an evolutionarily conserved family of regulatory factors that control microtubule dynamics and the organization of microtubule networks. ...In this Cell Science at a Glance article and the accompanying poster, we …
CLIP-associating proteins (CLASPs) form an evolutionarily conserved family of regulatory factors that control microtubule dyna …
New Insights Into Functions of IQ67-Domain Proteins.
Guo C, Zhou J, Li D. Guo C, et al. Front Plant Sci. 2021 Feb 18;11:614851. doi: 10.3389/fpls.2020.614851. eCollection 2020. Front Plant Sci. 2021. PMID: 33679817 Free PMC article. Review.
IQ67-domain (IQD) proteins, first identified in Arabidopsis and rice, are plant-specific calmodulin-binding proteins containing highly conserved motifs. ...Driven by comprehensive genome identification and analysis efforts, IQDs have now been characterized in …
IQ67-domain (IQD) proteins, first identified in Arabidopsis and rice, are plant-specific calmodulin-binding proteins co …
215 results