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19 results
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ATP-Sensitive Potassium Channels and Their Physiological and Pathophysiological Roles.
Tinker A, Aziz Q, Li Y, Specterman M. Tinker A, et al. Compr Physiol. 2018 Sep 14;8(4):1463-1511. doi: 10.1002/cphy.c170048. Compr Physiol. 2018. PMID: 30215858 Review.
They also respond to MgADP and are regulated by a number of cell signaling pathways. They have a rich and diverse pharmacology with a number of agents acting as specific inhibitors and activators. ...
They also respond to MgADP and are regulated by a number of cell signaling pathways. They have a rich and diverse pharmacology with a …
The Pharmacology of ATP-Sensitive K+ Channels (KATP).
Li Y, Aziz Q, Tinker A. Li Y, et al. Among authors: tinker a. Handb Exp Pharmacol. 2021;267:357-378. doi: 10.1007/164_2021_466. Handb Exp Pharmacol. 2021. PMID: 34247283
The tissue-specific expression of K(ATP) channel subunits coupled with their rich and diverse pharmacology makes K(ATP) channels attractive therapeutic targets in the treatment of endocrine and cardiovascular diseases....
The tissue-specific expression of K(ATP) channel subunits coupled with their rich and diverse pharmacology makes K(ATP) channels attr …
Programming for safe motherhood: a guide to action.
Koblinsky MA, Tinker A, Daly P. Koblinsky MA, et al. Among authors: tinker a. Health Policy Plan. 1994 Sep;9(3):252-66. doi: 10.1093/heapol/9.3.252. Health Policy Plan. 1994. PMID: 10137741 Review.
A typological approach with three hypothetical settings from resource poor to resource rich environments is used to address the variability in health behaviours and infrastructure encountered when programming for safe motherhood. ...
A typological approach with three hypothetical settings from resource poor to resource rich environments is used to address the varia …
Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes.
Pleasance E, Titmuss E, Williamson L, Kwan H, Culibrk L, Zhao EY, Dixon K, Fan K, Bowlby R, Jones MR, Shen Y, Grewal JK, Ashkani J, Wee K, Grisdale CJ, Thibodeau ML, Bozoky Z, Pearson H, Majounie E, Vira T, Shenwai R, Mungall KL, Chuah E, Davies A, Warren M, Reisle C, Bonakdar M, Taylor GA, Csizmok V, Chan SK, Zong Z, Bilobram S, Muhammadzadeh A, D'Souza D, Corbett RD, MacMillan D, Carreira M, Choo C, Bleile D, Sadeghi S, Zhang W, Wong T, Cheng D, Brown SD, Holt RA, Moore RA, Mungall AJ, Zhao Y, Nelson J, Fok A, Ma Y, Lee MKC, Lavoie JM, Mendis S, Karasinska JM, Deol B, Fisic A, Schaeffer DF, Yip S, Schrader K, Regier DA, Weymann D, Chia S, Gelmon K, Tinker A, Sun S, Lim H, Renouf DJ, Laskin J, Jones SJM, Marra MA. Pleasance E, et al. Among authors: tinker a. Nat Cancer. 2020 Apr;1(4):452-468. doi: 10.1038/s43018-020-0050-6. Epub 2020 Apr 13. Nat Cancer. 2020. PMID: 35121966
Mutation burden and immune signatures corresponded with overall survival and response to immunotherapy. Our data offer a rich resource for investigation of advanced cancers and interpretation of whole-genome and transcriptome sequencing in the context of a cancer clinic... …
Mutation burden and immune signatures corresponded with overall survival and response to immunotherapy. Our data offer a rich resourc …
Differences in Gut Microbiome Composition Between Sympatric Wild and Allopatric Laboratory Populations of Omnivorous Cockroaches.
Tinker KA, Ottesen EA. Tinker KA, et al. Front Microbiol. 2021 Jul 28;12:703785. doi: 10.3389/fmicb.2021.703785. eCollection 2021. Front Microbiol. 2021. PMID: 34394050 Free PMC article.
Cockroaches are a useful model for host-gut microbiome interactions due to their rich hindgut microbial community, omnivorous diet, and gregarious lifestyle. ...
Cockroaches are a useful model for host-gut microbiome interactions due to their rich hindgut microbial community, omnivorous diet, a …
A graph-based multi-sample test for identifying pathways associated with cancer progression.
Zhang Q, Mahdi G, Tinker J, Chen H. Zhang Q, et al. Among authors: tinker j. Comput Biol Chem. 2020 May 26;87:107285. doi: 10.1016/j.compbiolchem.2020.107285. Online ahead of print. Comput Biol Chem. 2020. PMID: 32521496
Our method is based on an expansion and refinement of the pathway being studied, followed by a graph-based multivariate test, which is very easy to implement in practice. The new test is applied to the rich Cancer Genome Atlas data to study the (epi)genetic alterations of …
Our method is based on an expansion and refinement of the pathway being studied, followed by a graph-based multivariate test, which is very …
Spatial epidemiological patterns suggest mechanisms of land-sea transmission for Sarcocystis neurona in a coastal marine mammal.
Burgess TL, Tinker MT, Miller MA, Smith WA, Bodkin JL, Murray MJ, Nichol LM, Saarinen JA, Larson S, Tomoleoni JA, Conrad PA, Johnson CK. Burgess TL, et al. Among authors: tinker mt. Sci Rep. 2020 Feb 28;10(1):3683. doi: 10.1038/s41598-020-60254-5. Sci Rep. 2020. PMID: 32111856 Free PMC article.
In California, habitats containing soft sediment exhibited greater risk than hard substrate or kelp beds. Consuming a diet rich in clams was also associated with increased exposure risk. These findings suggest a transmission pathway analogous to that described for Toxoplas …
In California, habitats containing soft sediment exhibited greater risk than hard substrate or kelp beds. Consuming a diet rich in cl …
Food limitation leads to behavioral diversification and dietary specialization in sea otters.
Tinker MT, Bentall G, Estes JA. Tinker MT, et al. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):560-5. doi: 10.1073/pnas.0709263105. Epub 2008 Jan 14. Proc Natl Acad Sci U S A. 2008. PMID: 18195370 Free PMC article.
Here we report on dietary and associated behavioral changes that occurred with the experimental translocation of sea otters from a food-poor to a food-rich environment. Although the diets of all individuals were broadly similar in the food-rich environment, a behavi …
Here we report on dietary and associated behavioral changes that occurred with the experimental translocation of sea otters from a food-poor …
Intake of small-to-medium-chain saturated fatty acids is associated with peripheral leukocyte telomere length in postmenopausal women.
Song Y, You NC, Song Y, Kang MK, Hou L, Wallace R, Eaton CB, Tinker LF, Liu S. Song Y, et al. Among authors: tinker lf. J Nutr. 2013 Jun;143(6):907-14. doi: 10.3945/jn.113.175422. Epub 2013 Apr 24. J Nutr. 2013. PMID: 23616516 Free PMC article.
We examined the direct relations of total and types of dietary fats and fat-rich foods to peripheral leukocyte TL. In 4029 apparently healthy postmenopausal women who participated in the Women's Health Initiative, intakes of total fat, individual fatty acids, and fat-ri
We examined the direct relations of total and types of dietary fats and fat-rich foods to peripheral leukocyte TL. In 4029 apparently …
The large-conductance Ca2+-activated K+ channel is essential for innate immunity.
Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW. Ahluwalia J, et al. Among authors: tinker a. Nature. 2004 Feb 26;427(6977):853-8. doi: 10.1038/nature02356. Nature. 2004. PMID: 14985765 Free PMC article. Retracted.
However, recent evidence indicates that the microbes might be killed by proteases, activated by the oxidase through the generation of a hypertonic, K+-rich and alkaline environment in the phagocytic vacuole. Here we show that K+ crosses the membrane through large-conductan …
However, recent evidence indicates that the microbes might be killed by proteases, activated by the oxidase through the generation of a hype …
19 results