Richard Meek[Author] - Search Results

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Potent De Novo Macrocyclic Peptides That Inhibit O-GlcNAc Transferase through an Allosteric Mechanism.

Alteen MG, Peacock H, Meek RW, Busmann JA, Zhu S, Davies GJ, Suga H, Vocadlo DJ. Alteen MG, et al. Among authors: meek rw. Angew Chem Int Ed Engl. 2023 Jan 26;62(5):e202215671. doi: 10.1002/anie.202215671. Epub 2022 Dec 27. Angew Chem Int Ed Engl. 2023. PMID: 36460613 Free article.

Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis.

Armstrong Z, Meek RW, Wu L, Blaza JN, Davies GJ. Armstrong Z, et al. Among authors: meek rw. Structure. 2022 Oct 6;30(10):1443-1451.e5. doi: 10.1016/j.str.2022.07.001. Epub 2022 Jul 29. Structure. 2022. PMID: 35907402 Free PMC article.

The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity.

Meek RW, Brockerman J, Fordwour OB, Zandberg WF, Davies GJ, Vocadlo DJ. Meek RW, et al. PLoS Biol. 2022 Sep 21;20(9):e3001764. doi: 10.1371/journal.pbio.3001764. eCollection 2022 Sep. PLoS Biol. 2022. PMID: 36129849 Free PMC article.

Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum.

Li J, Sharma M, Meek R, Alhifthi A, Armstrong Z, Soler NM, Lee M, Goddard-Borger ED, Blaza JN, Davies GJ, Williams SJ. Li J, et al. Among authors: meek r. Chem Sci. 2023 Sep 25;14(41):11429-11440. doi: 10.1039/d3sc01594g. eCollection 2023 Oct 25. Chem Sci. 2023. PMID: 37886098 Free PMC article.

A Bioorthogonal Precision Tool for Human N-Acetylglucosaminyltransferase V.

Liu Y, Bineva-Todd G, Meek RW, Mazo L, Piniello B, Moroz O, Burnap SA, Begum N, Ohara A, Roustan C, Tomita S, Kjaer S, Polizzi K, Struwe WB, Rovira C, Davies GJ, Schumann B. Liu Y, et al. Among authors: meek rw. J Am Chem Soc. 2024 Oct 2;146(39):26707-26718. doi: 10.1021/jacs.4c05955. Epub 2024 Sep 17. J Am Chem Soc. 2024. PMID: 39287665 Free PMC article.

Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT.

Meek RW, Blaza JN, Busmann JA, Alteen MG, Vocadlo DJ, Davies GJ. Meek RW, et al. Nat Commun. 2021 Nov 11;12(1):6508. doi: 10.1038/s41467-021-26796-6. Nat Commun. 2021. PMID: 34764280 Free PMC article.

Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.

Cadby IT, Basford SM, Nottingham R, Meek R, Lowry R, Lambert C, Tridgett M, Till R, Ahmad R, Fung R, Hobley L, Hughes WS, Moynihan PJ, Sockett RE, Lovering AL. Cadby IT, et al. Among authors: meek r. EMBO J. 2019 Sep 2;38(17):e100772. doi: 10.15252/embj.2018100772. Epub 2019 Jul 29. EMBO J. 2019. PMID: 31355487 Free PMC article.

Phage display uncovers a sequence motif that drives polypeptide binding to a conserved regulatory exosite of O-GlcNAc transferase.

Alteen MG, Meek RW, Kolappan S, Busmann JA, Cao J, O'Gara Z, Chou Y, Derda R, Davies GJ, Vocadlo DJ. Alteen MG, et al. Among authors: meek rw. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2303690120. doi: 10.1073/pnas.2303690120. Epub 2023 Oct 11. Proc Natl Acad Sci U S A. 2023. PMID: 37819980 Free PMC article.

A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase.

Alteen MG, Gros C, Meek RW, Cardoso DA, Busmann JA, Sangouard G, Deen MC, Tan HY, Shen DL, Russell CC, Davies GJ, Robinson PJ, McCluskey A, Vocadlo DJ. Alteen MG, et al. Among authors: meek rw. Angew Chem Int Ed Engl. 2020 Jun 8;59(24):9601-9609. doi: 10.1002/anie.202000621. Epub 2020 Apr 2. Angew Chem Int Ed Engl. 2020. PMID: 32092778

HIV Drugs Inhibit Transfer of Plasmids Carrying Extended-Spectrum β-Lactamase and Carbapenemase Genes.

Buckner MMC, Ciusa ML, Meek RW, Moorey AR, McCallum GE, Prentice EL, Reid JP, Alderwick LJ, Di Maio A, Piddock LJV. Buckner MMC, et al. Among authors: meek rw. mBio. 2020 Feb 25;11(1):e03355-19. doi: 10.1128/mBio.03355-19. mBio. 2020. PMID: 32098822 Free PMC article.

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