Richardson DR - Search Results

1

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

Lovejoy DB, Sharp DM, Seebacher N, Obeidy P, Prichard T, Stefani C, Basha MT, Sharpe PC, Jansson PJ, Kalinowski DS, Bernhardt PV, Richardson DR. Lovejoy DB, et al. Among authors: richardson dr. J Med Chem. 2012 Aug 23;55(16):7230-44. doi: 10.1021/jm300768u. Epub 2012 Aug 3. J Med Chem. 2012. PMID: 22861499

2

Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity.

Richardson DR, Bernhardt PV. Richardson DR, et al. J Biol Inorg Chem. 1999 Jun;4(3):266-73. doi: 10.1007/s007750050312. J Biol Inorg Chem. 1999. PMID: 10439071

3

The biologically active iron chelators 2-pyridylcarboxaldehyde isonicotinoylhydrazone, 2-pyridylcarboxaldehyde benzoylhydrazone monohydrate and 2-furaldehyde isonicotinoylhydrazone.

Richardson DR, Becker E, Bernhardt PV. Richardson DR, et al. Acta Crystallogr C. 1999 Dec 15;55 ( Pt 12):2102-5. doi: 10.1107/s0108270199011531. Acta Crystallogr C. 1999. PMID: 10641282

4

Effect of iron chelators with potent anti-proliferative activity on the expression of molecules involved in cell cycle progression and growth.

Gao J, Lovejoy D, Richardson DR. Gao J, et al. Among authors: richardson dr. Redox Rep. 1999;4(6):311-2. doi: 10.1179/135100099101534990. Redox Rep. 1999. PMID: 10772072 No abstract available.

5

2-hydroxy-1-naphthaldehyde 2-methylthiosemicarbazone.

Lovejoy DB, Richardson DR, Bernhardt PV. Lovejoy DB, et al. Among authors: richardson dr. Acta Crystallogr C. 2000 Mar;56 ( Pt 3):341-2. doi: 10.1107/S0108270199015140. Epub 2000 Mar 15. Acta Crystallogr C. 2000. PMID: 10777943 Free article. No abstract available.

6

Complexes of gallium(III) and other metal ions and their potential in the treatment of neoplasia.

Richardson DR, Lovejoy DB. Richardson DR, et al. Expert Opin Investig Drugs. 2000 Jun;9(6):1257-70. doi: 10.1517/13543784.9.6.1257. Expert Opin Investig Drugs. 2000. PMID: 11060741 Review.

7

Unprecedented oxidation of a biologically active aroylhydrazone chelator catalysed by iron(III): serendipitous identification of diacylhydrazine ligands with high iron chelation efficacy.

Bernhardt PV, Chin P, Richardson DR. Bernhardt PV, et al. Among authors: richardson dr. J Biol Inorg Chem. 2001 Oct;6(8):801-9. doi: 10.1007/s007750100258. J Biol Inorg Chem. 2001. PMID: 11713687

8

Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells.

Lovejoy DB, Richardson DR. Lovejoy DB, et al. Among authors: richardson dr. Blood. 2002 Jul 15;100(2):666-76. doi: 10.1182/blood.v100.2.666. Blood. 2002. PMID: 12091363 Free article.

9

Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311.

Chaston TB, Lovejoy DB, Watts RN, Richardson DR. Chaston TB, et al. Among authors: richardson dr. Clin Cancer Res. 2003 Jan;9(1):402-14. Clin Cancer Res. 2003. PMID: 12538494

10

Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents.

Becker EM, Lovejoy DB, Greer JM, Watts R, Richardson DR. Becker EM, et al. Among authors: richardson dr. Br J Pharmacol. 2003 Mar;138(5):819-30. doi: 10.1038/sj.bjp.0705089. Br J Pharmacol. 2003. PMID: 12642383 Free PMC article.

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