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Targeting XIAP for the treatment of malignancy.
Schimmer AD, Dalili S, Batey RA, Riedl SJ. Schimmer AD, et al. Among authors: riedl sj. Cell Death Differ. 2006 Feb;13(2):179-88. doi: 10.1038/sj.cdd.4401826. Cell Death Differ. 2006. PMID: 16322751 Review.
Structural basis for the inhibition of caspase-3 by XIAP.
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS. Riedl SJ, et al. Cell. 2001 Mar 9;104(5):791-800. doi: 10.1016/s0092-8674(01)00274-4. Cell. 2001. PMID: 11257232
Mechanism of XIAP-mediated inhibition of caspase-9.
Shiozaki EN, Chai J, Rigotti DJ, Riedl SJ, Li P, Srinivasula SM, Alnemri ES, Fairman R, Shi Y. Shiozaki EN, et al. Among authors: riedl sj. Mol Cell. 2003 Feb;11(2):519-27. doi: 10.1016/s1097-2765(03)00054-6. Mol Cell. 2003. PMID: 12620238
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
González-López M, Welsh K, Finlay D, Ardecky RJ, Ganji SR, Su Y, Yuan H, Teriete P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND. González-López M, et al. Among authors: riedl sj. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4332-6. doi: 10.1016/j.bmcl.2011.05.049. Epub 2011 May 24. Bioorg Med Chem Lett. 2011. PMID: 21680182 Free PMC article.
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
Ardecky RJ, Welsh K, Finlay D, Lee PS, González-López M, Ganji SR, Ravanan P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND. Ardecky RJ, et al. Among authors: riedl sj. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4253-7. doi: 10.1016/j.bmcl.2013.04.096. Epub 2013 May 14. Bioorg Med Chem Lett. 2013. PMID: 23743278 Free PMC article.
Structural basis for the activation of human procaspase-7.
Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS, Bode W. Riedl SJ, et al. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14790-5. doi: 10.1073/pnas.221580098. Proc Natl Acad Sci U S A. 2001. PMID: 11752425 Free PMC article.
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