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Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP.
Wist AD, Gu L, Riedl SJ, Shi Y, McLendon GL. Wist AD, et al. Among authors: riedl sj. Bioorg Med Chem. 2007 Apr 15;15(8):2935-43. doi: 10.1016/j.bmc.2007.02.010. Epub 2007 Feb 11. Bioorg Med Chem. 2007. PMID: 17336535
Structural basis for the inhibition of caspase-3 by XIAP.
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS. Riedl SJ, et al. Cell. 2001 Mar 9;104(5):791-800. doi: 10.1016/s0092-8674(01)00274-4. Cell. 2001. PMID: 11257232
Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.
Welsh K, Milutinovic S, Ardecky RJ, Gonzalez-Lopez M, Ganji SR, Teriete P, Finlay D, Riedl S, Matsuzawa S, Pinilla C, Houghten R, Vuori K, Reed JC, Cosford ND. Welsh K, et al. PLoS One. 2016 Sep 12;11(9):e0161952. doi: 10.1371/journal.pone.0161952. eCollection 2016. PLoS One. 2016. PMID: 27617834 Free PMC article.
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.
Scott FL, Denault JB, Riedl SJ, Shin H, Renatus M, Salvesen GS. Scott FL, et al. Among authors: riedl sj. EMBO J. 2005 Feb 9;24(3):645-55. doi: 10.1038/sj.emboj.7600544. Epub 2005 Jan 13. EMBO J. 2005. PMID: 15650747 Free PMC article.
Mechanism of XIAP-mediated inhibition of caspase-9.
Shiozaki EN, Chai J, Rigotti DJ, Riedl SJ, Li P, Srinivasula SM, Alnemri ES, Fairman R, Shi Y. Shiozaki EN, et al. Among authors: riedl sj. Mol Cell. 2003 Feb;11(2):519-27. doi: 10.1016/s1097-2765(03)00054-6. Mol Cell. 2003. PMID: 12620238
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
González-López M, Welsh K, Finlay D, Ardecky RJ, Ganji SR, Su Y, Yuan H, Teriete P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND. González-López M, et al. Among authors: riedl sj. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4332-6. doi: 10.1016/j.bmcl.2011.05.049. Epub 2011 May 24. Bioorg Med Chem Lett. 2011. PMID: 21680182 Free PMC article.
The elastase-PK101 structure: mechanism of an ultrasensitive activity-based probe revealed.
Lechtenberg BC, Kasperkiewicz P, Robinson H, Drag M, Riedl SJ. Lechtenberg BC, et al. Among authors: riedl sj. ACS Chem Biol. 2015 Apr 17;10(4):945-51. doi: 10.1021/cb500909n. Epub 2015 Jan 22. ACS Chem Biol. 2015. PMID: 25581168
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
Ardecky RJ, Welsh K, Finlay D, Lee PS, González-López M, Ganji SR, Ravanan P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND. Ardecky RJ, et al. Among authors: riedl sj. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4253-7. doi: 10.1016/j.bmcl.2013.04.096. Epub 2013 May 14. Bioorg Med Chem Lett. 2013. PMID: 23743278 Free PMC article.
Structure of the apoptotic protease-activating factor 1 bound to ADP.
Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y. Riedl SJ, et al. Nature. 2005 Apr 14;434(7035):926-33. doi: 10.1038/nature03465. Nature. 2005. PMID: 15829969
Structural basis for the activation of human procaspase-7.
Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS, Bode W. Riedl SJ, et al. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14790-5. doi: 10.1073/pnas.221580098. Proc Natl Acad Sci U S A. 2001. PMID: 11752425 Free PMC article.
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