Riendeau D - Search Results

1

Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.

Riendeau D, Aspiotis R, Ethier D, Gareau Y, Grimm EL, Guay J, Guiral S, Juteau H, Mancini JA, Méthot N, Rubin J, Friesen RW. Riendeau D, et al. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3352-5. doi: 10.1016/j.bmcl.2005.05.027. Bioorg Med Chem Lett. 2005. PMID: 15953724

2

Inhibition of inducible prostaglandin E(2) synthase by 15-deoxy-Delta(12,14)-prostaglandin J(2) and polyunsaturated fatty acids.

Quraishi O, Mancini JA, Riendeau D. Quraishi O, et al. Among authors: riendeau d. Biochem Pharmacol. 2002 Mar 15;63(6):1183-9. doi: 10.1016/s0006-2952(02)00844-4. Biochem Pharmacol. 2002. PMID: 11931852

3

Purification and characterization of recombinant microsomal prostaglandin E synthase-1.

Ouellet M, Falgueyret JP, Ear PH, Pen A, Mancini JA, Riendeau D, Percival MD. Ouellet M, et al. Among authors: riendeau d. Protein Expr Purif. 2002 Dec;26(3):489-95. doi: 10.1016/s1046-5928(02)00566-1. Protein Expr Purif. 2002. PMID: 12460774

4

Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model.

Claveau D, Sirinyan M, Guay J, Gordon R, Chan CC, Bureau Y, Riendeau D, Mancini JA. Claveau D, et al. Among authors: riendeau d. J Immunol. 2003 May 1;170(9):4738-44. doi: 10.4049/jimmunol.170.9.4738. J Immunol. 2003. PMID: 12707354

5

Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.

Riendeau D, Salem M, Styhler A, Ouellet M, Mancini JA, Li CS. Riendeau D, et al. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1201-3. doi: 10.1016/j.bmcl.2003.12.047. Bioorg Med Chem Lett. 2004. PMID: 14980665

6

Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile.

Boulet L, Ouellet M, Bateman KP, Ethier D, Percival MD, Riendeau D, Mancini JA, Méthot N. Boulet L, et al. Among authors: riendeau d. J Biol Chem. 2004 May 28;279(22):23229-37. doi: 10.1074/jbc.M400443200. Epub 2004 Mar 11. J Biol Chem. 2004. PMID: 15016822 Free article.

7

Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1.

Guay J, Bateman K, Gordon R, Mancini J, Riendeau D. Guay J, et al. Among authors: riendeau d. J Biol Chem. 2004 Jun 4;279(23):24866-72. doi: 10.1074/jbc.M403106200. Epub 2004 Mar 24. J Biol Chem. 2004. PMID: 15044444 Free article.

8

Substituted coumarins as potent 5-lipoxygenase inhibitors.

Grimm EL, Brideau C, Chauret N, Chan CC, Delorme D, Ducharme Y, Ethier D, Falgueyret JP, Friesen RW, Guay J, Hamel P, Riendeau D, Soucy-Breau C, Tagari P, Girard Y. Grimm EL, et al. Among authors: riendeau d. Bioorg Med Chem Lett. 2006 May 1;16(9):2528-31. doi: 10.1016/j.bmcl.2006.01.085. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16464579

9

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.

Côté B, Boulet L, Brideau C, Claveau D, Ethier D, Frenette R, Gagnon M, Giroux A, Guay J, Guiral S, Mancini J, Martins E, Massé F, Méthot N, Riendeau D, Rubin J, Xu D, Yu H, Ducharme Y, Friesen RW. Côté B, et al. Among authors: riendeau d. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20. doi: 10.1016/j.bmcl.2007.10.033. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 18029174

10

MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.

Xu D, Rowland SE, Clark P, Giroux A, Côté B, Guiral S, Salem M, Ducharme Y, Friesen RW, Méthot N, Mancini J, Audoly L, Riendeau D. Xu D, et al. Among authors: riendeau d. J Pharmacol Exp Ther. 2008 Sep;326(3):754-63. doi: 10.1124/jpet.108.138776. Epub 2008 Jun 4. J Pharmacol Exp Ther. 2008. PMID: 18524979

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