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321 results
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Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination.
Lai F, Damle SS, Ling KK, Rigo F. Lai F, et al. Among authors: rigo f. Mol Cell. 2020 Mar 5;77(5):1032-1043.e4. doi: 10.1016/j.molcel.2019.12.029. Epub 2020 Jan 7. Mol Cell. 2020. PMID: 31924447
The RNA tether from the poly(A) signal to the polymerase mediates coupling of transcription to cleavage and polyadenylation.
Rigo F, Kazerouninia A, Nag A, Martinson HG. Rigo F, et al. Mol Cell. 2005 Dec 9;20(5):733-45. doi: 10.1016/j.molcel.2005.09.026. Mol Cell. 2005. PMID: 16337597
Functional coupling of last-intron splicing and 3'-end processing to transcription in vitro: the poly(A) signal couples to splicing before committing to cleavage.
Rigo F, Martinson HG. Rigo F, et al. Mol Cell Biol. 2008 Jan;28(2):849-62. doi: 10.1128/MCB.01410-07. Epub 2007 Oct 29. Mol Cell Biol. 2008. PMID: 17967872 Free PMC article.
Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.
Rigo F, Hua Y, Chun SJ, Prakash TP, Krainer AR, Bennett CF. Rigo F, et al. Nat Chem Biol. 2012 Apr 15;8(6):555-61. doi: 10.1038/nchembio.939. Nat Chem Biol. 2012. PMID: 22504300 Free PMC article.
Antisense-based therapy for the treatment of spinal muscular atrophy.
Rigo F, Hua Y, Krainer AR, Bennett CF. Rigo F, et al. J Cell Biol. 2012 Oct 1;199(1):21-5. doi: 10.1083/jcb.201207087. J Cell Biol. 2012. PMID: 23027901 Free PMC article.
Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides.
Ward AJ, Norrbom M, Chun S, Bennett CF, Rigo F. Ward AJ, et al. Among authors: rigo f. Nucleic Acids Res. 2014 May;42(9):5871-9. doi: 10.1093/nar/gku184. Epub 2014 Mar 3. Nucleic Acids Res. 2014. PMID: 24589581 Free PMC article.
Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates.
Rigo F, Chun SJ, Norris DA, Hung G, Lee S, Matson J, Fey RA, Gaus H, Hua Y, Grundy JS, Krainer AR, Henry SP, Bennett CF. Rigo F, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):46-55. doi: 10.1124/jpet.113.212407. Epub 2014 Apr 30. J Pharmacol Exp Ther. 2014. PMID: 24784568 Free PMC article.
Antisense oligonucleotide-based therapies for diseases caused by pre-mRNA processing defects.
Rigo F, Seth PP, Bennett CF. Rigo F, et al. Adv Exp Med Biol. 2014;825:303-52. doi: 10.1007/978-1-4939-1221-6_9. Adv Exp Med Biol. 2014. PMID: 25201110 Review.
DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD.
Lim JW, Snider L, Yao Z, Tawil R, Van Der Maarel SM, Rigo F, Bennett CF, Filippova GN, Tapscott SJ. Lim JW, et al. Among authors: rigo f. Hum Mol Genet. 2015 Sep 1;24(17):4817-28. doi: 10.1093/hmg/ddv206. Epub 2015 Jun 3. Hum Mol Genet. 2015. PMID: 26041815 Free PMC article.
Poly(A) Signal-Dependent Transcription Termination Occurs through a Conformational Change Mechanism that Does Not Require Cleavage at the Poly(A) Site.
Zhang H, Rigo F, Martinson HG. Zhang H, et al. Among authors: rigo f. Mol Cell. 2015 Aug 6;59(3):437-48. doi: 10.1016/j.molcel.2015.06.008. Epub 2015 Jul 9. Mol Cell. 2015. PMID: 26166703
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