Riley JP - Search Results

1

Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines.

Cowden JM, Riley JP, Ma JY, Thurmond RL, Dunford PJ. Cowden JM, et al. Among authors: riley jp. Respir Res. 2010 Jun 24;11(1):86. doi: 10.1186/1465-9921-11-86. Respir Res. 2010. PMID: 20573261 Free PMC article.

2

Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.

Riley JP, Fuchs B, Sjöberg L, Nilsson GP, Karlsson L, Dahlén SE, Rao NL, Adner M. Riley JP, et al. Clin Sci (Lond). 2013 Dec;125(11):533-42. doi: 10.1042/CS20130092. Clin Sci (Lond). 2013. PMID: 23799245

3

Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo.

Cowden JM, Yu F, Challapalli M, Huang JF, Kim S, Fung-Leung WP, Ma JY, Riley JP, Zhang M, Dunford PJ, Thurmond RL. Cowden JM, et al. Among authors: riley jp. Inflamm Res. 2013 Jun;62(6):599-607. doi: 10.1007/s00011-013-0612-5. Epub 2013 Mar 27. Inflamm Res. 2013. PMID: 23532396 Free PMC article.

4

Azabenzthiazole inhibitors of leukotriene A₄ hydrolase.

Tanis VM, Bacani GM, Blevitt JM, Chrovian CC, Crawford S, De Leon A, Fourie AM, Gomez L, Grice CA, Herman K, Kearney AM, Landry-Bayle AM, Lee-Dutra A, Nelson J, Riley JP, Santillán A Jr, Wiener JJ, Xue X, Young AL. Tanis VM, et al. Among authors: riley jp. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7504-11. doi: 10.1016/j.bmcl.2012.10.036. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2012. PMID: 23127888

5

Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness.

Rao NL, Riley JP, Banie H, Xue X, Sun B, Crawford S, Lundeen KA, Yu F, Karlsson L, Fourie AM, Dunford PJ. Rao NL, et al. Among authors: riley jp. Am J Respir Crit Care Med. 2010 May 1;181(9):899-907. doi: 10.1164/rccm.200807-1158OC. Epub 2010 Jan 28. Am J Respir Crit Care Med. 2010. PMID: 20110560

6

The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.

Cowden JM, Yu F, Banie H, Farahani M, Ling P, Nguyen S, Riley JP, Zhang M, Zhu J, Dunford PJ, Thurmond RL. Cowden JM, et al. Among authors: riley jp. Ann Rheum Dis. 2014 Mar;73(3):600-8. doi: 10.1136/annrheumdis-2013-203832. Epub 2013 Oct 14. Ann Rheum Dis. 2014. PMID: 24126456 Free PMC article.

7

Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase.

Eccles W, Blevitt JM, Booker JN, Chrovian CC, Crawford S, de Leon AR, Deng X, Fourie AM, Grice CA, Herman K, Karlsson L, Kearney AM, Lee-Dutra A, Liang J, Luna R, Pippel D, Rao N, Riley JP, Santillán A, Savall B, Tanis VM, Xue X, Young AL. Eccles W, et al. Among authors: riley jp. Bioorg Med Chem Lett. 2013 Feb 1;23(3):811-5. doi: 10.1016/j.bmcl.2012.11.074. Epub 2012 Dec 5. Bioorg Med Chem Lett. 2013. PMID: 23260350

8

Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Grice CA, Tays KL, Savall BM, Wei J, Butler CR, Axe FU, Bembenek SD, Fourie AM, Dunford PJ, Lundeen K, Coles F, Xue X, Riley JP, Williams KN, Karlsson L, Edwards JP. Grice CA, et al. Among authors: riley jp. J Med Chem. 2008 Jul 24;51(14):4150-69. doi: 10.1021/jm701575k. Epub 2008 Jun 28. J Med Chem. 2008. PMID: 18588282

9

A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker.

Crawford S, Belajic D, Wei J, Riley JP, Dunford PJ, Bembenek S, Fourie A, Edwards JP, Karlsson L, Brunmark A, Wolin RL, Blevitt JM. Crawford S, et al. Among authors: riley jp. Mol Cancer Ther. 2008 Mar;7(3):492-9. doi: 10.1158/1535-7163.MCT-07-0307. Mol Cancer Ther. 2008. PMID: 18347137

10

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.

Rao NL, Dunford PJ, Xue X, Jiang X, Lundeen KA, Coles F, Riley JP, Williams KN, Grice CA, Edwards JP, Karlsson L, Fourie AM. Rao NL, et al. Among authors: riley jp. J Pharmacol Exp Ther. 2007 Jun;321(3):1154-60. doi: 10.1124/jpet.106.115436. Epub 2007 Mar 19. J Pharmacol Exp Ther. 2007. PMID: 17371808

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