Riley RJ - Search Results

1

Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential.

Moody GC, Griffin SJ, Mather AN, McGinnity DF, Riley RJ. Moody GC, et al. Among authors: riley rj. Xenobiotica. 1999 Jan;29(1):53-75. doi: 10.1080/004982599238812. Xenobiotica. 1999. PMID: 10078840

2

Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.

Weaver R, Graham KS, Beattie IG, Riley RJ. Weaver R, et al. Among authors: riley rj. Drug Metab Dispos. 2003 Jul;31(7):955-66. doi: 10.1124/dmd.31.7.955. Drug Metab Dispos. 2003. PMID: 12814974

3

Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA.

Williamson B, Soars AC, Owen A, White P, Riley RJ, Soars MG. Williamson B, et al. Among authors: riley rj. Xenobiotica. 2013 Oct;43(10):920-31. doi: 10.3109/00498254.2013.776194. Epub 2013 Mar 6. Xenobiotica. 2013. PMID: 23461378

4

Evaluation of the marmoset as a model species for drug glucuronidation.

Soars MG, Riley RJ, Burchell B. Soars MG, et al. Among authors: riley rj. Xenobiotica. 2001 Dec;31(12):849-60. doi: 10.1080/00498250110069690. Xenobiotica. 2001. PMID: 11780760

5

Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s.

McGinnity DF, Parker AJ, Soars M, Riley RJ. McGinnity DF, et al. Among authors: riley rj. Drug Metab Dispos. 2000 Nov;28(11):1327-34. Drug Metab Dispos. 2000. PMID: 11038161

6

Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.

Soars MG, Grime K, Riley RJ. Soars MG, et al. Among authors: riley rj. Xenobiotica. 2006 Apr;36(4):287-99. doi: 10.1080/00498250500446208. Xenobiotica. 2006. PMID: 16684709

7

The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions.

Grime K, Riley RJ. Grime K, et al. Among authors: riley rj. Curr Drug Metab. 2006 Apr;7(3):251-64. doi: 10.2174/138920006776359266. Curr Drug Metab. 2006. PMID: 16611020 Review.

8

The potential pharmacological and toxicological impact of P450 screening.

Riley RJ. Riley RJ. Curr Opin Drug Discov Devel. 2001 Jan;4(1):45-54. Curr Opin Drug Discov Devel. 2001. PMID: 11727322 Review.

9

Development of a generalized, quantitative physicochemical model of CYP3A4 inhibition for use in early drug discovery.

Riley RJ, Parker AJ, Trigg S, Manners CN. Riley RJ, et al. Pharm Res. 2001 May;18(5):652-5. doi: 10.1023/a:1011085411050. Pharm Res. 2001. PMID: 11465421

10

Predicting drug pharmacokinetics in humans from in vitro metabolism studies.

McGinnity DF, Riley RJ. McGinnity DF, et al. Among authors: riley rj. Biochem Soc Trans. 2001 May;29(Pt 2):135-9. doi: 10.1042/0300-5127:0290135. Biochem Soc Trans. 2001. PMID: 11356141

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